cAMP export by the fission yeast Schizosaccharomyces pombe

The fission yeast Schizosaccharomyces pombe produces a cAMP signal in response to glucose detection. Previous characterization of this signaling focused on intracellular levels of cAMP. Here, we find that the cAMP is secreted into the medium almost immediately. This is not due to PKA activation as m...

Descripción completa

Detalles Bibliográficos
Autores principales: Eberhard, Jeremy, Hoffman, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019093/
https://www.ncbi.nlm.nih.gov/pubmed/33829153
http://dx.doi.org/10.17912/micropub.biology.000384
_version_ 1783674310932561920
author Eberhard, Jeremy
Hoffman, Charles S.
author_facet Eberhard, Jeremy
Hoffman, Charles S.
author_sort Eberhard, Jeremy
collection PubMed
description The fission yeast Schizosaccharomyces pombe produces a cAMP signal in response to glucose detection. Previous characterization of this signaling focused on intracellular levels of cAMP. Here, we find that the cAMP is secreted into the medium almost immediately. This is not due to PKA activation as might have been expected. In addition, a strain that is highly deficient in drug efflux shows only a modest reduction in the secretion of cAMP to the growth medium. These observations reveal a previously unappreciated aspect of cAMP metabolism in an important model organism, leading to new questions regarding the mechanism and benefit of cAMP export in S. pombe.
format Online
Article
Text
id pubmed-8019093
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Caltech Library
record_format MEDLINE/PubMed
spelling pubmed-80190932021-04-06 cAMP export by the fission yeast Schizosaccharomyces pombe Eberhard, Jeremy Hoffman, Charles S. MicroPubl Biol New Finding The fission yeast Schizosaccharomyces pombe produces a cAMP signal in response to glucose detection. Previous characterization of this signaling focused on intracellular levels of cAMP. Here, we find that the cAMP is secreted into the medium almost immediately. This is not due to PKA activation as might have been expected. In addition, a strain that is highly deficient in drug efflux shows only a modest reduction in the secretion of cAMP to the growth medium. These observations reveal a previously unappreciated aspect of cAMP metabolism in an important model organism, leading to new questions regarding the mechanism and benefit of cAMP export in S. pombe. Caltech Library 2021-04-02 /pmc/articles/PMC8019093/ /pubmed/33829153 http://dx.doi.org/10.17912/micropub.biology.000384 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Eberhard, Jeremy
Hoffman, Charles S.
cAMP export by the fission yeast Schizosaccharomyces pombe
title cAMP export by the fission yeast Schizosaccharomyces pombe
title_full cAMP export by the fission yeast Schizosaccharomyces pombe
title_fullStr cAMP export by the fission yeast Schizosaccharomyces pombe
title_full_unstemmed cAMP export by the fission yeast Schizosaccharomyces pombe
title_short cAMP export by the fission yeast Schizosaccharomyces pombe
title_sort camp export by the fission yeast schizosaccharomyces pombe
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019093/
https://www.ncbi.nlm.nih.gov/pubmed/33829153
http://dx.doi.org/10.17912/micropub.biology.000384
work_keys_str_mv AT eberhardjeremy campexportbythefissionyeastschizosaccharomycespombe
AT hoffmancharless campexportbythefissionyeastschizosaccharomycespombe

Ejemplares similares