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Prevalence of joint hypermobility in children and adolescents: A systematic review and meta-analysis
BACKGROUND: The inconsistent results of different studies regarding the prevalence of joint hypermobility (JH) or joint laxity in children and adolescents made us conduct a meta-analysis on the prevalence of JH in this age group. MATERIALS AND METHODS: We searched electronic databases including Trip...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019126/ https://www.ncbi.nlm.nih.gov/pubmed/33824669 http://dx.doi.org/10.4103/jrms.JRMS_983_19 |
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author | Sobhani-Eraghi, Amir Motalebi, Mohsen Sarreshtehdari, Siavash Molazem-Sanandaji, Borzooyeh Hasanlu, Zahra |
author_facet | Sobhani-Eraghi, Amir Motalebi, Mohsen Sarreshtehdari, Siavash Molazem-Sanandaji, Borzooyeh Hasanlu, Zahra |
author_sort | Sobhani-Eraghi, Amir |
collection | PubMed |
description | BACKGROUND: The inconsistent results of different studies regarding the prevalence of joint hypermobility (JH) or joint laxity in children and adolescents made us conduct a meta-analysis on the prevalence of JH in this age group. MATERIALS AND METHODS: We searched electronic databases including Trip, Scopus, Medline, Embase, PubMed, and Google Scholar; some Iranian databases including Iran Medex and Magiran; and Scientific Information Database to find studies in which the prevalence of JH in children and adolescents had been reported since January 1990 to April 2017. In this process, two researchers evaluated the articles separately while they were not aware of each other's method, and they extracted and matched the information. RESULTS: Necessary data of twenty studies (15,097 boys and 6048 girls) were entered into this meta-analysis. The age range in these studies was 3–19 years. According to the meta-analysis conducted on the twenty studies, it was determined that the total prevalence of JH among children and adolescents was 34.1% (95% confidence interval [CI]: 33.3%–34.8%). Based on the results obtained from the studies, a significant heterogeneity (I(2) index equals to 99,415 and P ≤ 0.001) was shown, so we used random-effects model; moreover, the overall assessment of studies showed a statistically significant publication bias (P = 0.02). In total, the prevalence in girls was equal to 32.5% (95% CI: 31.4%–33.7%), and in boys, it was equal to 18.1% (95% CI: 17.2%–19.1%). CONCLUSION: According to this meta-analysis, studies showed high heterogeneity, and the prevalence of JH in children and adolescents around the world was equal to 34.1% (95% CI: 33.3%–34.8%) in total, whereas it was higher in girls and lower in older ages. |
format | Online Article Text |
id | pubmed-8019126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-80191262021-04-05 Prevalence of joint hypermobility in children and adolescents: A systematic review and meta-analysis Sobhani-Eraghi, Amir Motalebi, Mohsen Sarreshtehdari, Siavash Molazem-Sanandaji, Borzooyeh Hasanlu, Zahra J Res Med Sci Review Article BACKGROUND: The inconsistent results of different studies regarding the prevalence of joint hypermobility (JH) or joint laxity in children and adolescents made us conduct a meta-analysis on the prevalence of JH in this age group. MATERIALS AND METHODS: We searched electronic databases including Trip, Scopus, Medline, Embase, PubMed, and Google Scholar; some Iranian databases including Iran Medex and Magiran; and Scientific Information Database to find studies in which the prevalence of JH in children and adolescents had been reported since January 1990 to April 2017. In this process, two researchers evaluated the articles separately while they were not aware of each other's method, and they extracted and matched the information. RESULTS: Necessary data of twenty studies (15,097 boys and 6048 girls) were entered into this meta-analysis. The age range in these studies was 3–19 years. According to the meta-analysis conducted on the twenty studies, it was determined that the total prevalence of JH among children and adolescents was 34.1% (95% confidence interval [CI]: 33.3%–34.8%). Based on the results obtained from the studies, a significant heterogeneity (I(2) index equals to 99,415 and P ≤ 0.001) was shown, so we used random-effects model; moreover, the overall assessment of studies showed a statistically significant publication bias (P = 0.02). In total, the prevalence in girls was equal to 32.5% (95% CI: 31.4%–33.7%), and in boys, it was equal to 18.1% (95% CI: 17.2%–19.1%). CONCLUSION: According to this meta-analysis, studies showed high heterogeneity, and the prevalence of JH in children and adolescents around the world was equal to 34.1% (95% CI: 33.3%–34.8%) in total, whereas it was higher in girls and lower in older ages. Wolters Kluwer - Medknow 2020-11-26 /pmc/articles/PMC8019126/ /pubmed/33824669 http://dx.doi.org/10.4103/jrms.JRMS_983_19 Text en Copyright: © 2020 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Sobhani-Eraghi, Amir Motalebi, Mohsen Sarreshtehdari, Siavash Molazem-Sanandaji, Borzooyeh Hasanlu, Zahra Prevalence of joint hypermobility in children and adolescents: A systematic review and meta-analysis |
title | Prevalence of joint hypermobility in children and adolescents: A systematic review and meta-analysis |
title_full | Prevalence of joint hypermobility in children and adolescents: A systematic review and meta-analysis |
title_fullStr | Prevalence of joint hypermobility in children and adolescents: A systematic review and meta-analysis |
title_full_unstemmed | Prevalence of joint hypermobility in children and adolescents: A systematic review and meta-analysis |
title_short | Prevalence of joint hypermobility in children and adolescents: A systematic review and meta-analysis |
title_sort | prevalence of joint hypermobility in children and adolescents: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019126/ https://www.ncbi.nlm.nih.gov/pubmed/33824669 http://dx.doi.org/10.4103/jrms.JRMS_983_19 |
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