Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing

OBJECTIVES: Complete deficiency of alternative pathway (AP) complement factors, explained by homozygous mutations, is a well‐known risk factor for invasive bacterial infections; however, this is less obvious for heterozygous mutations. We describe two siblings with a heterozygous NM_001928.3(CFD):c....

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Detalles Bibliográficos
Autores principales: Langereis, Jeroen D, van der Molen, Renate G, de Kat Angelino, Corrie, Henriet, Stefanie S, de Jonge, Marien I, Joosten, Irma, Simons, Annet, Schuurs‐Hoeijmakers, Janneke HM, van Deuren, Marcel, van Aerde, Koen, van der Flier, Michiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019133/
https://www.ncbi.nlm.nih.gov/pubmed/33841879
http://dx.doi.org/10.1002/cti2.1256

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