UBC13 is an RNF213‐associated E2 ubiquitin‐conjugating enzyme, and Lysine 63‐linked ubiquitination by the RNF213‐UBC13 axis is responsible for angiogenic activity

Moyamoya disease (MMD) is a cryptogenic vascular disorder in the intracranial arteries. RING protein 213 (RNF213) is the susceptibility gene for MMD, and encodes a RING domain and a Walker motif. Herein, we identified UBC13 (UBE2N) as an E2 ubiquitin‐conjugating enzyme for RNF213 E3 ubiquitin ligase...

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Detalles Bibliográficos
Autores principales: Habu, Toshiyuki, Harada, Kouji H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019261/
https://www.ncbi.nlm.nih.gov/pubmed/33842849
http://dx.doi.org/10.1096/fba.2019-00092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019261/
https://www.ncbi.nlm.nih.gov/pubmed/33842849
http://dx.doi.org/10.1096/fba.2019-00092

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