Real-life use of remdesivir in hospitalized patients with COVID-19

OBJECTIVE: Controversial results on remdesivir efficacy have been reported. We aimed to report our real-life experience with the use of remdesivir from its availability in Spain. METHODS: We performed a descriptive study of all patients admitted for ≥48 hours with confirmed COVID-19 who received rem...

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Detalles Bibliográficos
Autores principales: Garcia-Vidal, Carolina, Meira, Fernanda, Cózar-Llistó, Alberto, Dueñas, Gerard, Puerta-Alcalde, Pedro, Garcia-Pouton, Nicole, Chumbita, Mariana, Cardozo, Celia, Hernandez-Meneses, Marta, Alonso-Navarro, Rodrigo, Rico, Verónica, Agüero, Daiana, Bodro, Marta, Morata, Laura, Jordan, Carlota, Lopera, Carlos, Ambrosioni, Juan, Segui, Ferran, Grafia, Nacho, Castro, Pedro, García, Felipe, Mensa, Josep, Martínez, José Antonio, Sanjuan, Gemma, Soriano, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedad Española de Quimioterapia 2021
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019465/
https://www.ncbi.nlm.nih.gov/pubmed/33675220
http://dx.doi.org/10.37201/req/018.2021
Descripción
Sumario:OBJECTIVE: Controversial results on remdesivir efficacy have been reported. We aimed to report our real-life experience with the use of remdesivir from its availability in Spain. METHODS: We performed a descriptive study of all patients admitted for ≥48 hours with confirmed COVID-19 who received remdesivir between the 1st of July and the 30th of September 2020. RESULTS: A total of 123 patients out of 242 admitted with COVID-19 at our hospital (50.8%) received remdesivir. Median age was 58 years, 61% were males and 56.9 % received at least one anti-inflammatory treatment. No adverse events requiring remdesivir discontinuation were reported. The need of intensive care unit admission, mechanical ventilation and 30-days mortality were 19.5%, 7.3% and 4.1%, respectively. CONCLUSION: In our real-life experience, the use of remdesivir in hospitalized patients with COVID-19 was associated with a low mortality rate and good safety profile.

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