Cargando…
Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population
Fractal analysis provides a global assessment of vascular networks (e.g., geometric complexity). We examined the association of diastolic left ventricular (LV) function with the retinal microvascular fractal dimension. A lower fractal dimension signifies a sparser retinal microvascular network. In 6...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019655/ https://www.ncbi.nlm.nih.gov/pubmed/33542474 http://dx.doi.org/10.1038/s41440-021-00623-3 |
_version_ | 1783674418776506368 |
---|---|
author | Wei, Fang-Fei Thijs, Lutgarde Melgarejo, Jesus D. Cauwenberghs, Nicholas Zhang, Zhen-Yu Liu, Chen Kuznetsova, Tatiana Struijker-Boudier, Harry A. J. Verhamme, Peter Dong, Yu-Gang Staessen, Jan A. |
author_facet | Wei, Fang-Fei Thijs, Lutgarde Melgarejo, Jesus D. Cauwenberghs, Nicholas Zhang, Zhen-Yu Liu, Chen Kuznetsova, Tatiana Struijker-Boudier, Harry A. J. Verhamme, Peter Dong, Yu-Gang Staessen, Jan A. |
author_sort | Wei, Fang-Fei |
collection | PubMed |
description | Fractal analysis provides a global assessment of vascular networks (e.g., geometric complexity). We examined the association of diastolic left ventricular (LV) function with the retinal microvascular fractal dimension. A lower fractal dimension signifies a sparser retinal microvascular network. In 628 randomly recruited Flemish individuals (51.3% women; mean age, 50.8 years), we measured diastolic LV function by echocardiography and the retinal microvascular fractal dimension by the box-counting method (Singapore I Vessel Assessment software, version 3.6). The left atrial volume index (LAVI), e′, E/e′ and retinal microvascular fractal dimension averaged (±SD) 24.3 ± 6.2 mL/m(2), 10.9 ± 3.6 cm/s, 6.96 ± 2.2, and 1.39 ± 0.05, respectively. The LAVI, E, e′ and E/e′ were associated (P < 0.001) with the retinal microvascular fractal dimension with association sizes (per 1 SD), amounting to −1.49 mL/m(2) (95% confidence interval, −1.98 to −1.01), 2.57 cm/s (1.31–3.84), 1.34 cm/s (1.07–1.60), and −0.74 (−0.91 to −0.57), respectively. With adjustments applied for potential covariables, the associations of E peak and E/e′ with the retinal microvascular fractal dimension remained significant (P ≤ 0.020). Over a median follow-up of 5.3 years, 18 deaths occurred. The crude and adjusted hazard ratios expressing the risk of all-cause mortality associated with a 1-SD increment in the retinal microvascular fractal dimension were 0.36 (0.23–0.57; P < 0.001) and 0.57 (0.34–0.96; P = 0.035), respectively. In the general population, a lower retinal microvascular fractal dimension was associated with greater E/e′, a measure of LV filling pressure. These observations can potentially be translated into new strategies for the prevention of diastolic LV dysfunction. |
format | Online Article Text |
id | pubmed-8019655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-80196552021-04-16 Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population Wei, Fang-Fei Thijs, Lutgarde Melgarejo, Jesus D. Cauwenberghs, Nicholas Zhang, Zhen-Yu Liu, Chen Kuznetsova, Tatiana Struijker-Boudier, Harry A. J. Verhamme, Peter Dong, Yu-Gang Staessen, Jan A. Hypertens Res Article Fractal analysis provides a global assessment of vascular networks (e.g., geometric complexity). We examined the association of diastolic left ventricular (LV) function with the retinal microvascular fractal dimension. A lower fractal dimension signifies a sparser retinal microvascular network. In 628 randomly recruited Flemish individuals (51.3% women; mean age, 50.8 years), we measured diastolic LV function by echocardiography and the retinal microvascular fractal dimension by the box-counting method (Singapore I Vessel Assessment software, version 3.6). The left atrial volume index (LAVI), e′, E/e′ and retinal microvascular fractal dimension averaged (±SD) 24.3 ± 6.2 mL/m(2), 10.9 ± 3.6 cm/s, 6.96 ± 2.2, and 1.39 ± 0.05, respectively. The LAVI, E, e′ and E/e′ were associated (P < 0.001) with the retinal microvascular fractal dimension with association sizes (per 1 SD), amounting to −1.49 mL/m(2) (95% confidence interval, −1.98 to −1.01), 2.57 cm/s (1.31–3.84), 1.34 cm/s (1.07–1.60), and −0.74 (−0.91 to −0.57), respectively. With adjustments applied for potential covariables, the associations of E peak and E/e′ with the retinal microvascular fractal dimension remained significant (P ≤ 0.020). Over a median follow-up of 5.3 years, 18 deaths occurred. The crude and adjusted hazard ratios expressing the risk of all-cause mortality associated with a 1-SD increment in the retinal microvascular fractal dimension were 0.36 (0.23–0.57; P < 0.001) and 0.57 (0.34–0.96; P = 0.035), respectively. In the general population, a lower retinal microvascular fractal dimension was associated with greater E/e′, a measure of LV filling pressure. These observations can potentially be translated into new strategies for the prevention of diastolic LV dysfunction. Springer Singapore 2021-02-04 2021 /pmc/articles/PMC8019655/ /pubmed/33542474 http://dx.doi.org/10.1038/s41440-021-00623-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wei, Fang-Fei Thijs, Lutgarde Melgarejo, Jesus D. Cauwenberghs, Nicholas Zhang, Zhen-Yu Liu, Chen Kuznetsova, Tatiana Struijker-Boudier, Harry A. J. Verhamme, Peter Dong, Yu-Gang Staessen, Jan A. Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population |
title | Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population |
title_full | Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population |
title_fullStr | Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population |
title_full_unstemmed | Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population |
title_short | Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population |
title_sort | diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a flemish population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019655/ https://www.ncbi.nlm.nih.gov/pubmed/33542474 http://dx.doi.org/10.1038/s41440-021-00623-3 |
work_keys_str_mv | AT weifangfei diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT thijslutgarde diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT melgarejojesusd diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT cauwenberghsnicholas diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT zhangzhenyu diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT liuchen diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT kuznetsovatatiana diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT struijkerboudierharryaj diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT verhammepeter diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT dongyugang diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation AT staessenjana diastolicleftventricularfunctioninrelationtotheretinalmicrovascularfractaldimensioninaflemishpopulation |