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COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM)
Mastocytosis is a neoplasm characterized by an accumulation of mast cells in various organs and increased risk for severe anaphylaxis in patients with concomitant allergies. Coronavirus disease 2019 (COVID-19) is a pandemic that is associated with a relatively high rate of severe lung disease and mo...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Academy of Allergy, Asthma & Immunology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019658/ https://www.ncbi.nlm.nih.gov/pubmed/33831618 http://dx.doi.org/10.1016/j.jaip.2021.03.041 |
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author | Bonadonna, Patrizia Brockow, Knut Niedoszytko, Marek Elberink, Hanneke Oude Akin, Cem Nedoszytko, Boguslaw Butterfield, Joseph H. Alvarez-Twose, Ivan Sotlar, Karl Schwaab, Juliana Jawhar, Mohamad Castells, Mariana Sperr, Wolfgang R. Hermine, Olivier Gotlib, Jason Zanotti, Roberta Reiter, Andreas Broesby-Olsen, Sigurd Bindslev-Jensen, Carsten Schwartz, Lawrence B. Horny, Hans-Peter Radia, Deepti Triggiani, Massimo Sabato, Vito Carter, Melody C. Siebenhaar, Frank Orfao, Alberto Grattan, Clive Metcalfe, Dean D. Arock, Michel Gulen, Theo Hartmann, Karin Valent, Peter |
author_facet | Bonadonna, Patrizia Brockow, Knut Niedoszytko, Marek Elberink, Hanneke Oude Akin, Cem Nedoszytko, Boguslaw Butterfield, Joseph H. Alvarez-Twose, Ivan Sotlar, Karl Schwaab, Juliana Jawhar, Mohamad Castells, Mariana Sperr, Wolfgang R. Hermine, Olivier Gotlib, Jason Zanotti, Roberta Reiter, Andreas Broesby-Olsen, Sigurd Bindslev-Jensen, Carsten Schwartz, Lawrence B. Horny, Hans-Peter Radia, Deepti Triggiani, Massimo Sabato, Vito Carter, Melody C. Siebenhaar, Frank Orfao, Alberto Grattan, Clive Metcalfe, Dean D. Arock, Michel Gulen, Theo Hartmann, Karin Valent, Peter |
author_sort | Bonadonna, Patrizia |
collection | PubMed |
description | Mastocytosis is a neoplasm characterized by an accumulation of mast cells in various organs and increased risk for severe anaphylaxis in patients with concomitant allergies. Coronavirus disease 2019 (COVID-19) is a pandemic that is associated with a relatively high rate of severe lung disease and mortality. The mortality is particularly high in those with certain comorbidities and increases with age. Recently, several companies have developed an effective vaccination against COVID-19. Although the reported frequency of severe side effects is low, there is an emerging discussion about the safety of COVID-19 vaccination in patients with severe allergies and mastocytosis. However, even in these patients, severe adverse reactions are rare. We therefore recommend the broad use of COVID-19 vaccination in patients with mastocytosis on a global basis. The only well-established exception is a known or suspected allergy against a constituent of the vaccine. Safety measures, including premedication and postvaccination observation, should be considered in all patients with mastocytosis, depending on the individual personal risk and overall situation in each case. The current article provides a summary of published data, observations, and expert opinion that form the basis of these recommendations. |
format | Online Article Text |
id | pubmed-8019658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Academy of Allergy, Asthma & Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-80196582021-04-06 COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM) Bonadonna, Patrizia Brockow, Knut Niedoszytko, Marek Elberink, Hanneke Oude Akin, Cem Nedoszytko, Boguslaw Butterfield, Joseph H. Alvarez-Twose, Ivan Sotlar, Karl Schwaab, Juliana Jawhar, Mohamad Castells, Mariana Sperr, Wolfgang R. Hermine, Olivier Gotlib, Jason Zanotti, Roberta Reiter, Andreas Broesby-Olsen, Sigurd Bindslev-Jensen, Carsten Schwartz, Lawrence B. Horny, Hans-Peter Radia, Deepti Triggiani, Massimo Sabato, Vito Carter, Melody C. Siebenhaar, Frank Orfao, Alberto Grattan, Clive Metcalfe, Dean D. Arock, Michel Gulen, Theo Hartmann, Karin Valent, Peter J Allergy Clin Immunol Pract Special Article Mastocytosis is a neoplasm characterized by an accumulation of mast cells in various organs and increased risk for severe anaphylaxis in patients with concomitant allergies. Coronavirus disease 2019 (COVID-19) is a pandemic that is associated with a relatively high rate of severe lung disease and mortality. The mortality is particularly high in those with certain comorbidities and increases with age. Recently, several companies have developed an effective vaccination against COVID-19. Although the reported frequency of severe side effects is low, there is an emerging discussion about the safety of COVID-19 vaccination in patients with severe allergies and mastocytosis. However, even in these patients, severe adverse reactions are rare. We therefore recommend the broad use of COVID-19 vaccination in patients with mastocytosis on a global basis. The only well-established exception is a known or suspected allergy against a constituent of the vaccine. Safety measures, including premedication and postvaccination observation, should be considered in all patients with mastocytosis, depending on the individual personal risk and overall situation in each case. The current article provides a summary of published data, observations, and expert opinion that form the basis of these recommendations. American Academy of Allergy, Asthma & Immunology 2021-06 2021-04-05 /pmc/articles/PMC8019658/ /pubmed/33831618 http://dx.doi.org/10.1016/j.jaip.2021.03.041 Text en © 2021 American Academy of Allergy, Asthma & Immunology. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Special Article Bonadonna, Patrizia Brockow, Knut Niedoszytko, Marek Elberink, Hanneke Oude Akin, Cem Nedoszytko, Boguslaw Butterfield, Joseph H. Alvarez-Twose, Ivan Sotlar, Karl Schwaab, Juliana Jawhar, Mohamad Castells, Mariana Sperr, Wolfgang R. Hermine, Olivier Gotlib, Jason Zanotti, Roberta Reiter, Andreas Broesby-Olsen, Sigurd Bindslev-Jensen, Carsten Schwartz, Lawrence B. Horny, Hans-Peter Radia, Deepti Triggiani, Massimo Sabato, Vito Carter, Melody C. Siebenhaar, Frank Orfao, Alberto Grattan, Clive Metcalfe, Dean D. Arock, Michel Gulen, Theo Hartmann, Karin Valent, Peter COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM) |
title | COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM) |
title_full | COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM) |
title_fullStr | COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM) |
title_full_unstemmed | COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM) |
title_short | COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM) |
title_sort | covid-19 vaccination in mastocytosis: recommendations of the european competence network on mastocytosis (ecnm) and american initiative in mast cell diseases (aim) |
topic | Special Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019658/ https://www.ncbi.nlm.nih.gov/pubmed/33831618 http://dx.doi.org/10.1016/j.jaip.2021.03.041 |
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