P-Selectin Blockade in the Treatment of Painful Vaso-Occlusive Crises in Sickle Cell Disease: A Spotlight on Crizanlizumab

Microvascular vaso-occlusion driven pain crisis is the hallmark of sickle cell disease with profound morbidity and increased mortality. Selectins, most notably P-selectins have an integral role in this phenomenon. P-selection was first identified in 1989. In 2019, after 3 decades of basic, translati...

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Detalles Bibliográficos
Autores principales: Karki, Nabin Raj, Kutlar, Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019662/
https://www.ncbi.nlm.nih.gov/pubmed/33833562
http://dx.doi.org/10.2147/JPR.S278285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019662/
https://www.ncbi.nlm.nih.gov/pubmed/33833562
http://dx.doi.org/10.2147/JPR.S278285

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