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The engine initiating tissue regeneration: does a common mechanism exist during evolution?
A successful tissue regeneration is a very complex process that requires a precise coordination of many molecular, cellular and physiological events. One of the critical steps is to convert the injury signals into regeneration signals to initiate tissue regeneration. Although many efforts have been...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019671/ https://www.ncbi.nlm.nih.gov/pubmed/33817749 http://dx.doi.org/10.1186/s13619-020-00073-1 |
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author | Liu, Yanmei Lou, Wilson Pak-Kin Fei, Ji-Feng |
author_facet | Liu, Yanmei Lou, Wilson Pak-Kin Fei, Ji-Feng |
author_sort | Liu, Yanmei |
collection | PubMed |
description | A successful tissue regeneration is a very complex process that requires a precise coordination of many molecular, cellular and physiological events. One of the critical steps is to convert the injury signals into regeneration signals to initiate tissue regeneration. Although many efforts have been made to investigate the mechanisms triggering tissue regeneration, the fundamental questions remain unresolved. One of the major obstacles is that the injury and the initiation of regeneration are two highly coupled processes and hard to separate from one another. In this article, we review the major events occurring at the early injury/regeneration stage in a range of species, and discuss the possible common mechanisms during initiation of tissue regeneration. |
format | Online Article Text |
id | pubmed-8019671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-80196712021-04-12 The engine initiating tissue regeneration: does a common mechanism exist during evolution? Liu, Yanmei Lou, Wilson Pak-Kin Fei, Ji-Feng Cell Regen Review A successful tissue regeneration is a very complex process that requires a precise coordination of many molecular, cellular and physiological events. One of the critical steps is to convert the injury signals into regeneration signals to initiate tissue regeneration. Although many efforts have been made to investigate the mechanisms triggering tissue regeneration, the fundamental questions remain unresolved. One of the major obstacles is that the injury and the initiation of regeneration are two highly coupled processes and hard to separate from one another. In this article, we review the major events occurring at the early injury/regeneration stage in a range of species, and discuss the possible common mechanisms during initiation of tissue regeneration. Springer Singapore 2021-04-05 /pmc/articles/PMC8019671/ /pubmed/33817749 http://dx.doi.org/10.1186/s13619-020-00073-1 Text en © The Author(s) 2022, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Liu, Yanmei Lou, Wilson Pak-Kin Fei, Ji-Feng The engine initiating tissue regeneration: does a common mechanism exist during evolution? |
title | The engine initiating tissue regeneration: does a common mechanism exist during evolution? |
title_full | The engine initiating tissue regeneration: does a common mechanism exist during evolution? |
title_fullStr | The engine initiating tissue regeneration: does a common mechanism exist during evolution? |
title_full_unstemmed | The engine initiating tissue regeneration: does a common mechanism exist during evolution? |
title_short | The engine initiating tissue regeneration: does a common mechanism exist during evolution? |
title_sort | engine initiating tissue regeneration: does a common mechanism exist during evolution? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019671/ https://www.ncbi.nlm.nih.gov/pubmed/33817749 http://dx.doi.org/10.1186/s13619-020-00073-1 |
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