A Heart Failure-Associated SCN5A Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel

Na(v)1.5, encoded by the gene SCN5A, is the predominant voltage-gated sodium channel expressed in the heart. It initiates the cardiac action potential and thus is crucial for normal heart rhythm and function. Dysfunctions in Na(v)1.5 have been involved in multiple congenital or acquired cardiac path...

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Detalles Bibliográficos
Autores principales: Zheng, Yang, Wan, Xiaoping, Yang, Dandan, Ramirez-Navarro, Angelina, Liu, Haiyan, Fu, Ji-Dong, Deschênes, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019726/
https://www.ncbi.nlm.nih.gov/pubmed/33828490
http://dx.doi.org/10.3389/fphys.2021.661429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019726/
https://www.ncbi.nlm.nih.gov/pubmed/33828490
http://dx.doi.org/10.3389/fphys.2021.661429

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