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Mapping Network Activity in Sleep

It was in the influenza pandemic of 1918 that von Economo identified specific brain regions regulating sleep and wake. Since then researchers have used a variety of tools to determine how the brain shifts between states of consciousness. In every enterprise new tools have validated existing data, co...

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Detalles Bibliográficos
Autores principales: Shiromani, Priyattam J., Blanco-Centurion, Carlos, Vidal-Ortiz, Aurelio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019804/
https://www.ncbi.nlm.nih.gov/pubmed/33828453
http://dx.doi.org/10.3389/fnins.2021.646468
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author Shiromani, Priyattam J.
Blanco-Centurion, Carlos
Vidal-Ortiz, Aurelio
author_facet Shiromani, Priyattam J.
Blanco-Centurion, Carlos
Vidal-Ortiz, Aurelio
author_sort Shiromani, Priyattam J.
collection PubMed
description It was in the influenza pandemic of 1918 that von Economo identified specific brain regions regulating sleep and wake. Since then researchers have used a variety of tools to determine how the brain shifts between states of consciousness. In every enterprise new tools have validated existing data, corrected errors and made new discoveries to advance science. The brain is a challenge but new tools can disentangle the brain network. We summarize the newest tool, a miniature microscope, that provides unprecedented view of activity of glia and neurons in freely behaving mice. With this tool we have observed that the activity of a majority of GABA and MCH neurons in the lateral hypothalamus is heavily biased toward sleep. We suggest that miniscope data identifies activity at the cellular level in normal versus diseased brains, and also in response to specific hypnotics. Shifts in activity in small networks across the brain will help identify point of criticality that switches the brain from wake to sleep.
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spelling pubmed-80198042021-04-06 Mapping Network Activity in Sleep Shiromani, Priyattam J. Blanco-Centurion, Carlos Vidal-Ortiz, Aurelio Front Neurosci Neuroscience It was in the influenza pandemic of 1918 that von Economo identified specific brain regions regulating sleep and wake. Since then researchers have used a variety of tools to determine how the brain shifts between states of consciousness. In every enterprise new tools have validated existing data, corrected errors and made new discoveries to advance science. The brain is a challenge but new tools can disentangle the brain network. We summarize the newest tool, a miniature microscope, that provides unprecedented view of activity of glia and neurons in freely behaving mice. With this tool we have observed that the activity of a majority of GABA and MCH neurons in the lateral hypothalamus is heavily biased toward sleep. We suggest that miniscope data identifies activity at the cellular level in normal versus diseased brains, and also in response to specific hypnotics. Shifts in activity in small networks across the brain will help identify point of criticality that switches the brain from wake to sleep. Frontiers Media S.A. 2021-03-22 /pmc/articles/PMC8019804/ /pubmed/33828453 http://dx.doi.org/10.3389/fnins.2021.646468 Text en Copyright © 2021 Shiromani, Blanco-Centurion and Vidal-Ortiz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Shiromani, Priyattam J.
Blanco-Centurion, Carlos
Vidal-Ortiz, Aurelio
Mapping Network Activity in Sleep
title Mapping Network Activity in Sleep
title_full Mapping Network Activity in Sleep
title_fullStr Mapping Network Activity in Sleep
title_full_unstemmed Mapping Network Activity in Sleep
title_short Mapping Network Activity in Sleep
title_sort mapping network activity in sleep
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019804/
https://www.ncbi.nlm.nih.gov/pubmed/33828453
http://dx.doi.org/10.3389/fnins.2021.646468
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