Cargando…

Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats

Background: Accumulating evidence suggested that bone marrow mesenchymal stem cells (BMSCs) have therapeutic potential for diabetes and heart diseases. However, the effects of BMSC on reducing myocardial fibrosis need to be optimized. This study aimed to investigate the mechanism of adiponectin (APN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Ke, Cai, Huabo, Cai, Simin, Hong, Yucai, Zhang, Xiaoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019808/ https://www.ncbi.nlm.nih.gov/pubmed/33829019 http://dx.doi.org/10.3389/fcell.2021.644160

Ejemplares similares

Corrigendum: Adiponectin modified BMSCs alleviate heart fibrosis via inhibition TGF-beta1/smad in diabetic rats
por: Meng, Ke, et al.
Publicado: (2023)

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2019)

Corrigendum: Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2020)

Contribution of TGF-Beta-Mediated NLRP3-HMGB1 Activation to Tubulointerstitial Fibrosis in Rat With Angiotensin II-Induced Chronic Kidney Disease
por: Zhang, Kaimin, et al.
Publicado: (2020)

ASPH Regulates Osteogenic Differentiation and Cellular Senescence of BMSCs
por: Peng, Hui, et al.
Publicado: (2020)

TMT-Based Proteomic Explores the Influence of DHEA on the Osteogenic Differentiation of hBMSCs
por: Liang, Xiaonan, et al.
Publicado: (2021)

Role of adiponectin in osteoarthritis
por: Feng, Xinyuan, et al.
Publicado: (2022)

FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration
por: Ge, Jun, et al.
Publicado: (2020)

β-Ecdysterone Enhanced Bone Regeneration Through the BMP-2/SMAD/RUNX2/Osterix Signaling Pathway
por: Yan, Cai-Ping, et al.
Publicado: (2022)

A Functional SMAD2/3 Binding Site in the PEX11β Promoter Identifies a Role for TGFβ in Peroxisome Proliferation in Humans
por: Azadi, Afsoon S., et al.
Publicado: (2020)

Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial–Mesenchymal Transition-Like Response During Ventricle Regeneration
por: Peng, Yuanyuan, et al.
Publicado: (2021)

Expression Profile Analysis of Long Non-coding RNA in OVX Models-Derived BMSCs for Postmenopausal Osteoporosis by RNA Sequencing and Bioinformatics
por: Gu, Huijie, et al.
Publicado: (2021)

Corrigendum: Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial–Mesenchymal Transition-Like Response During Ventricle Regeneration
por: Peng, Yuanyuan, et al.
Publicado: (2021)

Lack of Adiponectin Drives Hyperosteoclastogenesis in Lipoatrophic Mice
por: Madel, Maria-Bernadette, et al.
Publicado: (2021)

Smad7-overexpressing rat BMSCs inhibit the fibrosis of hepatic stellate cells by regulating the TGF-β1/Smad signaling pathway
por: Wu, Shi-Pin, et al.
Publicado: (2017)

Long-Term Release of Dexamethasone With a Polycaprolactone-Coated Electrode Alleviates Fibrosis in Cochlear Implantation
por: Chen, Dongxiu, et al.
Publicado: (2021)

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway
por: Fu, Yuanyuan, et al.
Publicado: (2021)

Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling
por: Bai, Jian, et al.
Publicado: (2021)

Paracrine Effects of Recombinant Human Adiponectin Promote Bone Regeneration
por: Gong, Yanping, et al.
Publicado: (2021)

Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress
por: Dai, Wenzhang, et al.
Publicado: (2021)

Lessons in aging from Myc knockout mouse models
por: Prochownik, Edward V., et al.
Publicado: (2023)

Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex
por: Shi, Meng, et al.
Publicado: (2022)

Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation
por: Chen, Fanghui, et al.
Publicado: (2021)

CircFAM120B Blocks the Development of Colorectal Cancer by Activating TGF-Beta Receptor II Expression via Targeting miR-645
por: Yu, You, et al.
Publicado: (2021)

The Role of SMAD2/3 in Human Embryonic Stem Cells
por: Yang, Jie, et al.
Publicado: (2020)

Metformin Attenuates Renal Fibrosis in a Mouse Model of Adenine-Induced Renal Injury Through Inhibiting TGF-β1 Signaling Pathways
por: Yi, Hao, et al.
Publicado: (2021)

Transcriptome-Wide m6A Methylome and m6A-Modified Gene Analysis in Asthma
por: Sun, Deyang, et al.
Publicado: (2022)

miR-29b-3p Inhibitor Alleviates Hypomethylation-Related Aberrations Through a Feedback Loop Between miR-29b-3p and DNA Methylation in Cardiomyocytes
por: Wu, Fang, et al.
Publicado: (2022)

Mitochondrial tRNA Mutation and Regulation of the Adiponectin Pathway in Maternally Inherited Hypertension in Chinese Han
por: Bai, Jing, et al.
Publicado: (2021)

HYAL-2–WWOX–SMAD4 Signaling in Cell Death and Anticancer Response
por: Hsu, Li-Jin, et al.
Publicado: (2016)

SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway
por: Zhang, Jinhang, et al.
Publicado: (2018)

Circ0083429 Regulates Osteoarthritis Progression via the Mir-346/SMAD3 Axis
por: Yao, Teng, et al.
Publicado: (2021)

A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo
por: Bertolio, Marcela Soledad, et al.
Publicado: (2021)

The Roles of TGF-β Signaling in Cerebrovascular Diseases
por: Zhang, Yizhe, et al.
Publicado: (2020)

Diverse Role of TGF-β in Kidney Disease
por: Gu, Yue-Yu, et al.
Publicado: (2020)

TGF-β Signaling and Resistance to Cancer Therapy
por: Zhang, Maoduo, et al.
Publicado: (2021)

Editorial: TGF-β and BMP signaling in cancer
por: Yan, Xiaohua, et al.
Publicado: (2022)

Expression of Concern: Mitochondrial tRNA mutation and regulation of the adiponectin pathway in maternally inherited hypertension in Chinese Han
Publicado: (2022)

Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis
por: Guo, Qingyuan, et al.
Publicado: (2020)

Network Pharmacology and Experimental Validation Reveal the Effects of Chidamide Combined With Aspirin on Acute Myeloid Leukemia-Myelodysplastic Syndrome Cells Through PI3K/AKT Pathway
por: Liang, Simin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uo51qe7vkbrf9g2fcihvk7jioh