Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease

The aggregation of α-synuclein is a hallmark of Parkinson's disease (PD) and a variety of related neurological disorders. A number of mutations in this protein, including A30P and A53T, are associated with familial forms of the disease. Patients carrying the A30P mutation typically exhibit a si...

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Detalles Bibliográficos
Autores principales: Perni, Michele, van der Goot, Annemieke, Limbocker, Ryan, van Ham, Tjakko J., Aprile, Francesco A., Xu, Catherine K., Flagmeier, Patrick, Thijssen, Karen, Sormanni, Pietro, Fusco, Giuliana, Chen, Serene W., Challa, Pavan K., Kirkegaard, Julius B., Laine, Romain F., Ma, Kai Yu, Müller, Martin B. D., Sinnige, Tessa, Kumita, Janet R., Cohen, Samuel I. A., Seinstra, Renée, Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Barbut, Denise, De Simone, Alfonso, Knowles, Tuomas P. J., Zasloff, Michael, Nollen, Ellen A. A., Vendruscolo, Michele, Dobson, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019828/
https://www.ncbi.nlm.nih.gov/pubmed/33829010
http://dx.doi.org/10.3389/fcell.2021.552549

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