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Cabozantinib Reverses Topotecan Resistance in Human Non-Small Cell Lung Cancer NCI-H460/TPT10 Cell Line and Tumor Xenograft Model

Cabozantinib (CBZ) is a small molecule tyrosine kinase receptor inhibitor, which could also inhibit the ABCG2 transporter function. Therefore, CBZ could re-sensitize cancer cells that are resistant to ABCG2 substrate drugs including topotecan (TPT). However, its reversal effect against TPT resistanc...

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Detalles Bibliográficos
Autores principales:	Lei, Zi-Ning, Teng, Qiu-Xu, Gupta, Pranav, Zhang, Wei, Narayanan, Silpa, Yang, Dong-Hua, Wurpel, John N. D., Fan, Ying-Fang, Chen, Zhe-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019832/ https://www.ncbi.nlm.nih.gov/pubmed/33829017 http://dx.doi.org/10.3389/fcell.2021.640957

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