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Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients
INTRODUCTION: Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characte...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Neuroscience Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019840/ https://www.ncbi.nlm.nih.gov/pubmed/33850613 http://dx.doi.org/10.32598/bcn.11.6.1100.1 |
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author | Simani, Leila Rezaei, Omidvar Ryan, Fari Sadeghi, Masoumeh Hooshmandi, Etrat Ramezani, Mahtab Pakdaman, Hossin |
author_facet | Simani, Leila Rezaei, Omidvar Ryan, Fari Sadeghi, Masoumeh Hooshmandi, Etrat Ramezani, Mahtab Pakdaman, Hossin |
author_sort | Simani, Leila |
collection | PubMed |
description | INTRODUCTION: Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characteristics in epileptic patients is unclear. METHODS: The current study enrolled patients with Epileptic Seizure (ES) to evaluate their serum concentration of CoQ10 and to investigate whether a relationship exists between CoQ10 levels with the duration, frequency, and type of seizure. RESULTS: A total of 39 patients with epileptic seizures and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99±5.93 vs (ng/ml). 16.48±4.20 (ng/ml) P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels. CONCLUSION: These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients. |
format | Online Article Text |
id | pubmed-8019840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Iranian Neuroscience Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-80198402021-04-12 Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients Simani, Leila Rezaei, Omidvar Ryan, Fari Sadeghi, Masoumeh Hooshmandi, Etrat Ramezani, Mahtab Pakdaman, Hossin Basic Clin Neurosci Research Paper INTRODUCTION: Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characteristics in epileptic patients is unclear. METHODS: The current study enrolled patients with Epileptic Seizure (ES) to evaluate their serum concentration of CoQ10 and to investigate whether a relationship exists between CoQ10 levels with the duration, frequency, and type of seizure. RESULTS: A total of 39 patients with epileptic seizures and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99±5.93 vs (ng/ml). 16.48±4.20 (ng/ml) P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels. CONCLUSION: These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients. Iranian Neuroscience Society 2020 2020-11-01 /pmc/articles/PMC8019840/ /pubmed/33850613 http://dx.doi.org/10.32598/bcn.11.6.1100.1 Text en Copyright© 2020 Iranian Neuroscience Society This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Research Paper Simani, Leila Rezaei, Omidvar Ryan, Fari Sadeghi, Masoumeh Hooshmandi, Etrat Ramezani, Mahtab Pakdaman, Hossin Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients |
title | Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients |
title_full | Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients |
title_fullStr | Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients |
title_full_unstemmed | Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients |
title_short | Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients |
title_sort | coenzyme q10 insufficiency contributes to the duration and frequency of seizures in epileptic patients |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019840/ https://www.ncbi.nlm.nih.gov/pubmed/33850613 http://dx.doi.org/10.32598/bcn.11.6.1100.1 |
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