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Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients

INTRODUCTION: Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characte...

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Autores principales: Simani, Leila, Rezaei, Omidvar, Ryan, Fari, Sadeghi, Masoumeh, Hooshmandi, Etrat, Ramezani, Mahtab, Pakdaman, Hossin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019840/
https://www.ncbi.nlm.nih.gov/pubmed/33850613
http://dx.doi.org/10.32598/bcn.11.6.1100.1
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author Simani, Leila
Rezaei, Omidvar
Ryan, Fari
Sadeghi, Masoumeh
Hooshmandi, Etrat
Ramezani, Mahtab
Pakdaman, Hossin
author_facet Simani, Leila
Rezaei, Omidvar
Ryan, Fari
Sadeghi, Masoumeh
Hooshmandi, Etrat
Ramezani, Mahtab
Pakdaman, Hossin
author_sort Simani, Leila
collection PubMed
description INTRODUCTION: Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characteristics in epileptic patients is unclear. METHODS: The current study enrolled patients with Epileptic Seizure (ES) to evaluate their serum concentration of CoQ10 and to investigate whether a relationship exists between CoQ10 levels with the duration, frequency, and type of seizure. RESULTS: A total of 39 patients with epileptic seizures and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99±5.93 vs (ng/ml). 16.48±4.20 (ng/ml) P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels. CONCLUSION: These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients.
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spelling pubmed-80198402021-04-12 Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients Simani, Leila Rezaei, Omidvar Ryan, Fari Sadeghi, Masoumeh Hooshmandi, Etrat Ramezani, Mahtab Pakdaman, Hossin Basic Clin Neurosci Research Paper INTRODUCTION: Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characteristics in epileptic patients is unclear. METHODS: The current study enrolled patients with Epileptic Seizure (ES) to evaluate their serum concentration of CoQ10 and to investigate whether a relationship exists between CoQ10 levels with the duration, frequency, and type of seizure. RESULTS: A total of 39 patients with epileptic seizures and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99±5.93 vs (ng/ml). 16.48±4.20 (ng/ml) P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels. CONCLUSION: These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients. Iranian Neuroscience Society 2020 2020-11-01 /pmc/articles/PMC8019840/ /pubmed/33850613 http://dx.doi.org/10.32598/bcn.11.6.1100.1 Text en Copyright© 2020 Iranian Neuroscience Society This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Research Paper
Simani, Leila
Rezaei, Omidvar
Ryan, Fari
Sadeghi, Masoumeh
Hooshmandi, Etrat
Ramezani, Mahtab
Pakdaman, Hossin
Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients
title Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients
title_full Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients
title_fullStr Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients
title_full_unstemmed Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients
title_short Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients
title_sort coenzyme q10 insufficiency contributes to the duration and frequency of seizures in epileptic patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019840/
https://www.ncbi.nlm.nih.gov/pubmed/33850613
http://dx.doi.org/10.32598/bcn.11.6.1100.1
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