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Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn
INTRODUCTION: The interaction between antiepileptic drugs and brain electrical stimulation is a potential therapy to control seizures in patients with pharmacoresistance to drugs. So, the present study aimed to design to determine the effect of a subeffective dose of sodium valproate combined with l...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Neuroscience Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019847/ https://www.ncbi.nlm.nih.gov/pubmed/33850620 http://dx.doi.org/10.32598/bcn.11.6.1392.2 |
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author | Zalkhani, Raha Moazedi, Ahmad Ali Ghotbeddin, Zohreh Pourmahdi, Mahdi |
author_facet | Zalkhani, Raha Moazedi, Ahmad Ali Ghotbeddin, Zohreh Pourmahdi, Mahdi |
author_sort | Zalkhani, Raha |
collection | PubMed |
description | INTRODUCTION: The interaction between antiepileptic drugs and brain electrical stimulation is a potential therapy to control seizures in patients with pharmacoresistance to drugs. So, the present study aimed to design to determine the effect of a subeffective dose of sodium valproate combined with low-frequency electrical stimulation during kindling. METHODS: One tripolar electrode was implanted stereotactically in the CA1 hippocampus of male Wistar rats. One week after surgery, the rats were kindled by electrical stimulation of hippocampus in a rapid manner (12 stimulations/day) for 6 days with sodium valproate alone or combined with low-frequency electrical stimulation (four packages contained 200 monophasic square wave pulses of 0.1-ms duration at 1 Hz, immediately after kindling stimulations). The duration of afterdischarge, maximum latency to stages 4 and 5, and the maximum duration of these stages were recorded by electromadule during kindling. RESULTS: Application of sodium valproate with low-frequency electrical stimulation caused a reduction in cumulative afterdischarge duration. The maximum latency to the onset of stage 5 seizure increased after sodium valproate application alone, without having a significant effect on the fourth stage. Our findings showed reductions in the seizures duration and increasing in the latency times of both stages after the application of sodium valproate with low-frequency electrical stimulation. CONCLUSION: It seems that usage of sodium valproate with low-frequency electrical stimulation during kindling was more effective to suppress the epileptic activity than its administration alone and may have a critical role on the antiepileptic effects of sodium valproate. |
format | Online Article Text |
id | pubmed-8019847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Iranian Neuroscience Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-80198472021-04-12 Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn Zalkhani, Raha Moazedi, Ahmad Ali Ghotbeddin, Zohreh Pourmahdi, Mahdi Basic Clin Neurosci Research Paper INTRODUCTION: The interaction between antiepileptic drugs and brain electrical stimulation is a potential therapy to control seizures in patients with pharmacoresistance to drugs. So, the present study aimed to design to determine the effect of a subeffective dose of sodium valproate combined with low-frequency electrical stimulation during kindling. METHODS: One tripolar electrode was implanted stereotactically in the CA1 hippocampus of male Wistar rats. One week after surgery, the rats were kindled by electrical stimulation of hippocampus in a rapid manner (12 stimulations/day) for 6 days with sodium valproate alone or combined with low-frequency electrical stimulation (four packages contained 200 monophasic square wave pulses of 0.1-ms duration at 1 Hz, immediately after kindling stimulations). The duration of afterdischarge, maximum latency to stages 4 and 5, and the maximum duration of these stages were recorded by electromadule during kindling. RESULTS: Application of sodium valproate with low-frequency electrical stimulation caused a reduction in cumulative afterdischarge duration. The maximum latency to the onset of stage 5 seizure increased after sodium valproate application alone, without having a significant effect on the fourth stage. Our findings showed reductions in the seizures duration and increasing in the latency times of both stages after the application of sodium valproate with low-frequency electrical stimulation. CONCLUSION: It seems that usage of sodium valproate with low-frequency electrical stimulation during kindling was more effective to suppress the epileptic activity than its administration alone and may have a critical role on the antiepileptic effects of sodium valproate. Iranian Neuroscience Society 2020 2020-11-01 /pmc/articles/PMC8019847/ /pubmed/33850620 http://dx.doi.org/10.32598/bcn.11.6.1392.2 Text en Copyright© 2020 Iranian Neuroscience Society This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Research Paper Zalkhani, Raha Moazedi, Ahmad Ali Ghotbeddin, Zohreh Pourmahdi, Mahdi Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn |
title | Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn |
title_full | Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn |
title_fullStr | Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn |
title_full_unstemmed | Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn |
title_short | Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn |
title_sort | interaction of sodium valproate with low-frequency electrical stimulation during kindlingn |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019847/ https://www.ncbi.nlm.nih.gov/pubmed/33850620 http://dx.doi.org/10.32598/bcn.11.6.1392.2 |
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