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Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients

Objective: The purpose of this study was to identify the difference between dual energy spectral computed tomography (DECT) and magnetic resonance imaging (MRI) used to detect liver/cardiac iron content in Myelodysplastic syndrome (MDS) patients with differently adjusted serum ferritin (ASF) levels....

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Autores principales: Zhang, Yao, Xiao, Chao, Li, Jing, Song, Lu-xi, Zhao, You-shan, Han, Shuang, Li, Zhao-wei, Guo, Cha, Zhao, Jun-gong, Chang, Chun-kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019931/
https://www.ncbi.nlm.nih.gov/pubmed/33828991
http://dx.doi.org/10.3389/fonc.2021.646946
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author Zhang, Yao
Xiao, Chao
Li, Jing
Song, Lu-xi
Zhao, You-shan
Han, Shuang
Li, Zhao-wei
Guo, Cha
Zhao, Jun-gong
Chang, Chun-kang
author_facet Zhang, Yao
Xiao, Chao
Li, Jing
Song, Lu-xi
Zhao, You-shan
Han, Shuang
Li, Zhao-wei
Guo, Cha
Zhao, Jun-gong
Chang, Chun-kang
author_sort Zhang, Yao
collection PubMed
description Objective: The purpose of this study was to identify the difference between dual energy spectral computed tomography (DECT) and magnetic resonance imaging (MRI) used to detect liver/cardiac iron content in Myelodysplastic syndrome (MDS) patients with differently adjusted serum ferritin (ASF) levels. Method: Liver and cardiac iron content were detected by DECT and MRI. Patients were divided into different subgroups according to the level of ASF. The receiver operating characteristic curve (ROC) analysis was applied in each subgroup. The correlation between iron content detected by DECT/MRI and ASF was analyzed in each subgroup. Result: ROC curves showed that liver virtual iron content (LVIC) Az was significantly less than liver iron concentration (LIC) Az in the subgroup with ASF < 1,000 ng/ml. There was no significant difference between LVIC Az and LIC Az in the subgroup with 1,000 ≤ ASF < 2,500 ng/ml and 2,500 ≤ ASF < 5,000 ng/ml. LVIC Az was significantly higher than LIC Az in the subgroup with ASF <5,000 and 5,000 ≤ ASF ng/ml. In patients undergoing DECT and MRI examination on the same day, ASF was significantly correlated with LVIC, whereas no significant correlation was observed between ASF and LIC. After removing the data of ASF > 5,000 mg/L in LIC, LIC became correlated with ASF. There was no significant difference between the subgroup with 2,500 ≤ ASF < 5,000 ng/ml and 5,000 ng/ml ≤ ASF in LIC expression. Furthermore, both LIC and liver VIC had significant correlations with ASF in patients with ASF < 2,500 ng/ml, while LVIC was still correlated with ASF, LIC was not correlated with ASF in patients with 2,500 ng/ml ≤ ASF. Moreover, neither cardiac VIC nor myocardial iron content (MIC) were correlated with ASF in these subgroups. Conclusion: MRI and DECT were complementary to each other in liver iron detection. In MDS patients with high iron content, such as ASF ≥ 5,000 ng/ml, DECT was more reliable than the MRI in the assessment of iron content. But in patients with low iron content, such as ASF < 1,000 ng/ml, MRI is more reliable than DECT. Therefore, for the sake of more accurately evaluating the iron content, the appropriate detection method can be selected according to ASF.
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spelling pubmed-80199312021-04-06 Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients Zhang, Yao Xiao, Chao Li, Jing Song, Lu-xi Zhao, You-shan Han, Shuang Li, Zhao-wei Guo, Cha Zhao, Jun-gong Chang, Chun-kang Front Oncol Oncology Objective: The purpose of this study was to identify the difference between dual energy spectral computed tomography (DECT) and magnetic resonance imaging (MRI) used to detect liver/cardiac iron content in Myelodysplastic syndrome (MDS) patients with differently adjusted serum ferritin (ASF) levels. Method: Liver and cardiac iron content were detected by DECT and MRI. Patients were divided into different subgroups according to the level of ASF. The receiver operating characteristic curve (ROC) analysis was applied in each subgroup. The correlation between iron content detected by DECT/MRI and ASF was analyzed in each subgroup. Result: ROC curves showed that liver virtual iron content (LVIC) Az was significantly less than liver iron concentration (LIC) Az in the subgroup with ASF < 1,000 ng/ml. There was no significant difference between LVIC Az and LIC Az in the subgroup with 1,000 ≤ ASF < 2,500 ng/ml and 2,500 ≤ ASF < 5,000 ng/ml. LVIC Az was significantly higher than LIC Az in the subgroup with ASF <5,000 and 5,000 ≤ ASF ng/ml. In patients undergoing DECT and MRI examination on the same day, ASF was significantly correlated with LVIC, whereas no significant correlation was observed between ASF and LIC. After removing the data of ASF > 5,000 mg/L in LIC, LIC became correlated with ASF. There was no significant difference between the subgroup with 2,500 ≤ ASF < 5,000 ng/ml and 5,000 ng/ml ≤ ASF in LIC expression. Furthermore, both LIC and liver VIC had significant correlations with ASF in patients with ASF < 2,500 ng/ml, while LVIC was still correlated with ASF, LIC was not correlated with ASF in patients with 2,500 ng/ml ≤ ASF. Moreover, neither cardiac VIC nor myocardial iron content (MIC) were correlated with ASF in these subgroups. Conclusion: MRI and DECT were complementary to each other in liver iron detection. In MDS patients with high iron content, such as ASF ≥ 5,000 ng/ml, DECT was more reliable than the MRI in the assessment of iron content. But in patients with low iron content, such as ASF < 1,000 ng/ml, MRI is more reliable than DECT. Therefore, for the sake of more accurately evaluating the iron content, the appropriate detection method can be selected according to ASF. Frontiers Media S.A. 2021-03-22 /pmc/articles/PMC8019931/ /pubmed/33828991 http://dx.doi.org/10.3389/fonc.2021.646946 Text en Copyright © 2021 Zhang, Xiao, Li, Song, Zhao, Han, Li, Guo, Zhao and Chang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Yao
Xiao, Chao
Li, Jing
Song, Lu-xi
Zhao, You-shan
Han, Shuang
Li, Zhao-wei
Guo, Cha
Zhao, Jun-gong
Chang, Chun-kang
Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients
title Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients
title_full Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients
title_fullStr Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients
title_full_unstemmed Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients
title_short Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients
title_sort comparative study on iron content detection by energy spectral ct and mri in mds patients
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019931/
https://www.ncbi.nlm.nih.gov/pubmed/33828991
http://dx.doi.org/10.3389/fonc.2021.646946
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