Reduction BACE1 expression via suppressing NF-κB mediated signaling by Tamibarotene in a mouse model of Alzheimer’s disease

This present study examined the effect of Tamibarotene (AM80) in APP/PS1 mice, a well-established AD mouse model. AM80 was intraperitoneal administered to 3-month-old APP/PS1 mice at a dose of 5 mg/kg/day for 16 weeks. The results clearly showed that AM80 could reduce amyloid-β peptides through impa...

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Detalles Bibliográficos
Autores principales: Qiao, Aimin, Li, Jieyi, Hu, Yaohua, Wang, Jinquan, Zhao, Zizhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019995/
https://www.ncbi.nlm.nih.gov/pubmed/33842919
http://dx.doi.org/10.1016/j.ibneur.2021.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019995/
https://www.ncbi.nlm.nih.gov/pubmed/33842919
http://dx.doi.org/10.1016/j.ibneur.2021.02.004

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