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Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma
OBJECTIVE: To investigate changes in DTI (Diffusion Tensor Imaging) parameters in brainstem subcortical auditory pathways after Gamma Knife Radiosurgery (GKR) in patients with intracanalicular vestibular schwannoma (ICVS) and to analyze the relationship between tumor volume and ADC (apparent diffusi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Istanbul Medeniyet University
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020186/ https://www.ncbi.nlm.nih.gov/pubmed/33828884 http://dx.doi.org/10.5222/MMJ.2021.15564 |
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author | Cesme, Dilek Hacer Alkan, Alpay Gultekin, Mehmet Ali Sari, Lutfullah Alkan, Gokberk Seyithanoglu, Mehmet Hakan Hatiboglu, Mustafa Aziz |
author_facet | Cesme, Dilek Hacer Alkan, Alpay Gultekin, Mehmet Ali Sari, Lutfullah Alkan, Gokberk Seyithanoglu, Mehmet Hakan Hatiboglu, Mustafa Aziz |
author_sort | Cesme, Dilek Hacer |
collection | PubMed |
description | OBJECTIVE: To investigate changes in DTI (Diffusion Tensor Imaging) parameters in brainstem subcortical auditory pathways after Gamma Knife Radiosurgery (GKR) in patients with intracanalicular vestibular schwannoma (ICVS) and to analyze the relationship between tumor volume and ADC (apparent diffusion coefficient) and FA (fractional anisotropy) values. METHOD: Seventeen patients with ICVS were evaluated before and after GKR. ADC and FA values of the lateral lemniscus (LL) and inferior colliculus (IC) and tumor volume were calculated. Patients who responded to GKR were classified as Group 1 and those who did not respond adequately as Group 2. The relationship between ADC and FA values and changes in tumor volume were analyzed. RESULTS: Tumor volume significantly decreased after GKR. ADC values obtained from the tumor increased after GKR (p:0.002). There was no significant difference in LL and IC before and after GKR in terms of FA and ADC values (n:17). There was a positive correlation between response to treatment and contralateral LL ADC values after GKR (p=0.005, r:0.652). There was a negative correlation between contralateral IC FA values after GKR and response to treatment (p=0.017, r: -0.568). There was a significant difference between Groups 1 and 2 in regards to contralateral LL ADC (p=0.03) and IC FA values (p=0.017). CONCLUSION: Since the cochlear nerve and subcortical auditory pathways have low regeneration potential after nerve damage, ADC and FA changes in LL and IC may be explained with the presence of intracanalicular tumors prior to GKR. Since GKR does not cause additional damage to the subcortical auditory pathways at the brainstem level, we think that GKR is a noninvasive treatment method that can be used safely in patients with ICVS. |
format | Online Article Text |
id | pubmed-8020186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Istanbul Medeniyet University |
record_format | MEDLINE/PubMed |
spelling | pubmed-80201862021-04-06 Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma Cesme, Dilek Hacer Alkan, Alpay Gultekin, Mehmet Ali Sari, Lutfullah Alkan, Gokberk Seyithanoglu, Mehmet Hakan Hatiboglu, Mustafa Aziz Medeni Med J Original Study OBJECTIVE: To investigate changes in DTI (Diffusion Tensor Imaging) parameters in brainstem subcortical auditory pathways after Gamma Knife Radiosurgery (GKR) in patients with intracanalicular vestibular schwannoma (ICVS) and to analyze the relationship between tumor volume and ADC (apparent diffusion coefficient) and FA (fractional anisotropy) values. METHOD: Seventeen patients with ICVS were evaluated before and after GKR. ADC and FA values of the lateral lemniscus (LL) and inferior colliculus (IC) and tumor volume were calculated. Patients who responded to GKR were classified as Group 1 and those who did not respond adequately as Group 2. The relationship between ADC and FA values and changes in tumor volume were analyzed. RESULTS: Tumor volume significantly decreased after GKR. ADC values obtained from the tumor increased after GKR (p:0.002). There was no significant difference in LL and IC before and after GKR in terms of FA and ADC values (n:17). There was a positive correlation between response to treatment and contralateral LL ADC values after GKR (p=0.005, r:0.652). There was a negative correlation between contralateral IC FA values after GKR and response to treatment (p=0.017, r: -0.568). There was a significant difference between Groups 1 and 2 in regards to contralateral LL ADC (p=0.03) and IC FA values (p=0.017). CONCLUSION: Since the cochlear nerve and subcortical auditory pathways have low regeneration potential after nerve damage, ADC and FA changes in LL and IC may be explained with the presence of intracanalicular tumors prior to GKR. Since GKR does not cause additional damage to the subcortical auditory pathways at the brainstem level, we think that GKR is a noninvasive treatment method that can be used safely in patients with ICVS. Istanbul Medeniyet University 2021 2021-03-26 /pmc/articles/PMC8020186/ /pubmed/33828884 http://dx.doi.org/10.5222/MMJ.2021.15564 Text en © Copyright Istanbul Medeniyet University Faculty of Medicine. http://creativecommons.org/licenses/by-nc/4.0/ This journal is published by Logos Medical Publishing. Licenced by Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) |
spellingShingle | Original Study Cesme, Dilek Hacer Alkan, Alpay Gultekin, Mehmet Ali Sari, Lutfullah Alkan, Gokberk Seyithanoglu, Mehmet Hakan Hatiboglu, Mustafa Aziz Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma |
title | Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma |
title_full | Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma |
title_fullStr | Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma |
title_full_unstemmed | Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma |
title_short | Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma |
title_sort | evaluation of brainstem subcortical auditory pathways with diffusion tensor imaging after gamma knife radiosurgery in intracanalicular vestibular schwannoma |
topic | Original Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020186/ https://www.ncbi.nlm.nih.gov/pubmed/33828884 http://dx.doi.org/10.5222/MMJ.2021.15564 |
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