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Comparing soleus injections and gastrocnemius injections of botulinum toxin for treating adult spastic foot drop: a monocentric observational study
OBJECTIVE: Outcome differences between selective abobotulinumtoxin type A (aboBoNT/A) injections into the soleus (SOL) and gastrocnemius (GAS) muscles were investigated in post-stroke patients with spastic foot drop. METHODS: A monocentric observational study was conducted at a university hospital b...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020232/ https://www.ncbi.nlm.nih.gov/pubmed/33784844 http://dx.doi.org/10.1177/0300060521998208 |
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author | Hefter, Harald Nickels, Werner Samadzadeh, Sara Rosenthal, Dietmar |
author_facet | Hefter, Harald Nickels, Werner Samadzadeh, Sara Rosenthal, Dietmar |
author_sort | Hefter, Harald |
collection | PubMed |
description | OBJECTIVE: Outcome differences between selective abobotulinumtoxin type A (aboBoNT/A) injections into the soleus (SOL) and gastrocnemius (GAS) muscles were investigated in post-stroke patients with spastic foot drop. METHODS: A monocentric observational study was conducted at a university hospital botulinum toxin clinic including 24 free-walking adult, botulinum toxin-naive patients with post-stroke hemiplegia. AboBoNT/A (800 MU in 4 mL saline) was injected into the SOL or GAS muscle under electromyographic guidance. After 30 days post-injection, the effect of aboBoNT/A injection was assessed by patients. The treating physician scored spasticity and measured angles at the knee and ankle joint and gait speed. RESULTS: After 30 days, significant improvements of subjective and objective outcome measures were observed. No significant difference was observed in the modified Ashworth scale, gait speed, ankle and knee angles, or their angle combinations between the SOL and GAS groups. Tendencies toward greater active range of motion (RoM) improvement in the SOL group and passive RoM improvement in the GAS group were observed. The difference between active and passive ankle extensions plus knee flexions was significantly larger in the SOL group. CONCLUSIONS: Selective 800 MU aboBoNT/A injections into the SOL or GAS muscle were effective but without relevant clinical difference. |
format | Online Article Text |
id | pubmed-8020232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-80202322021-04-16 Comparing soleus injections and gastrocnemius injections of botulinum toxin for treating adult spastic foot drop: a monocentric observational study Hefter, Harald Nickels, Werner Samadzadeh, Sara Rosenthal, Dietmar J Int Med Res Retrospective Clinical Research Report OBJECTIVE: Outcome differences between selective abobotulinumtoxin type A (aboBoNT/A) injections into the soleus (SOL) and gastrocnemius (GAS) muscles were investigated in post-stroke patients with spastic foot drop. METHODS: A monocentric observational study was conducted at a university hospital botulinum toxin clinic including 24 free-walking adult, botulinum toxin-naive patients with post-stroke hemiplegia. AboBoNT/A (800 MU in 4 mL saline) was injected into the SOL or GAS muscle under electromyographic guidance. After 30 days post-injection, the effect of aboBoNT/A injection was assessed by patients. The treating physician scored spasticity and measured angles at the knee and ankle joint and gait speed. RESULTS: After 30 days, significant improvements of subjective and objective outcome measures were observed. No significant difference was observed in the modified Ashworth scale, gait speed, ankle and knee angles, or their angle combinations between the SOL and GAS groups. Tendencies toward greater active range of motion (RoM) improvement in the SOL group and passive RoM improvement in the GAS group were observed. The difference between active and passive ankle extensions plus knee flexions was significantly larger in the SOL group. CONCLUSIONS: Selective 800 MU aboBoNT/A injections into the SOL or GAS muscle were effective but without relevant clinical difference. SAGE Publications 2021-03-30 /pmc/articles/PMC8020232/ /pubmed/33784844 http://dx.doi.org/10.1177/0300060521998208 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Retrospective Clinical Research Report Hefter, Harald Nickels, Werner Samadzadeh, Sara Rosenthal, Dietmar Comparing soleus injections and gastrocnemius injections of botulinum toxin for treating adult spastic foot drop: a monocentric observational study |
title | Comparing soleus injections and gastrocnemius injections of botulinum
toxin for treating adult spastic foot drop: a monocentric observational
study |
title_full | Comparing soleus injections and gastrocnemius injections of botulinum
toxin for treating adult spastic foot drop: a monocentric observational
study |
title_fullStr | Comparing soleus injections and gastrocnemius injections of botulinum
toxin for treating adult spastic foot drop: a monocentric observational
study |
title_full_unstemmed | Comparing soleus injections and gastrocnemius injections of botulinum
toxin for treating adult spastic foot drop: a monocentric observational
study |
title_short | Comparing soleus injections and gastrocnemius injections of botulinum
toxin for treating adult spastic foot drop: a monocentric observational
study |
title_sort | comparing soleus injections and gastrocnemius injections of botulinum
toxin for treating adult spastic foot drop: a monocentric observational
study |
topic | Retrospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020232/ https://www.ncbi.nlm.nih.gov/pubmed/33784844 http://dx.doi.org/10.1177/0300060521998208 |
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