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Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study

INTRODUCTION: Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders). Current studies show clinical meaningful improvements only in one thi...

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Autores principales: Müller, Patrick, Vellage, Anne‐Katrin, Schmicker, Marlen, Menze, Inga, Grothe, Michel J., Teipel, Stefan J., Müller, Notger G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020325/
https://www.ncbi.nlm.nih.gov/pubmed/33842683
http://dx.doi.org/10.1002/trc2.12153
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author Müller, Patrick
Vellage, Anne‐Katrin
Schmicker, Marlen
Menze, Inga
Grothe, Michel J.
Teipel, Stefan J.
Müller, Notger G.
author_facet Müller, Patrick
Vellage, Anne‐Katrin
Schmicker, Marlen
Menze, Inga
Grothe, Michel J.
Teipel, Stefan J.
Müller, Notger G.
author_sort Müller, Patrick
collection PubMed
description INTRODUCTION: Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors. METHODS: Here we investigate structural magnetic resonance imaging of the basal forebrain cholinergic system volume (BF(vol)) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n = 18; 59 to 75 years). RESULTS: We observed that the cognitive response to galantamine, more specifically the attention‐dependent filtering performance in a delayed match‐to‐sample working memory task, correlated with BF(vol): Only participants with high BF(vol) showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process. DISCUSSION: Future studies need to assess whether BF(vol) may serve as a predictor of the galantamine response in AD patients, too.
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spelling pubmed-80203252021-04-08 Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study Müller, Patrick Vellage, Anne‐Katrin Schmicker, Marlen Menze, Inga Grothe, Michel J. Teipel, Stefan J. Müller, Notger G. Alzheimers Dement (N Y) Research Articles INTRODUCTION: Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors. METHODS: Here we investigate structural magnetic resonance imaging of the basal forebrain cholinergic system volume (BF(vol)) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n = 18; 59 to 75 years). RESULTS: We observed that the cognitive response to galantamine, more specifically the attention‐dependent filtering performance in a delayed match‐to‐sample working memory task, correlated with BF(vol): Only participants with high BF(vol) showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process. DISCUSSION: Future studies need to assess whether BF(vol) may serve as a predictor of the galantamine response in AD patients, too. John Wiley and Sons Inc. 2021-04-05 /pmc/articles/PMC8020325/ /pubmed/33842683 http://dx.doi.org/10.1002/trc2.12153 Text en © 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Müller, Patrick
Vellage, Anne‐Katrin
Schmicker, Marlen
Menze, Inga
Grothe, Michel J.
Teipel, Stefan J.
Müller, Notger G.
Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study
title Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study
title_full Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study
title_fullStr Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study
title_full_unstemmed Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study
title_short Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study
title_sort structural mri of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—a randomized controlled double‐blinded crossover study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020325/
https://www.ncbi.nlm.nih.gov/pubmed/33842683
http://dx.doi.org/10.1002/trc2.12153
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