Cargando…
Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study
INTRODUCTION: Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders). Current studies show clinical meaningful improvements only in one thi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020325/ https://www.ncbi.nlm.nih.gov/pubmed/33842683 http://dx.doi.org/10.1002/trc2.12153 |
_version_ | 1783674561088192512 |
---|---|
author | Müller, Patrick Vellage, Anne‐Katrin Schmicker, Marlen Menze, Inga Grothe, Michel J. Teipel, Stefan J. Müller, Notger G. |
author_facet | Müller, Patrick Vellage, Anne‐Katrin Schmicker, Marlen Menze, Inga Grothe, Michel J. Teipel, Stefan J. Müller, Notger G. |
author_sort | Müller, Patrick |
collection | PubMed |
description | INTRODUCTION: Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors. METHODS: Here we investigate structural magnetic resonance imaging of the basal forebrain cholinergic system volume (BF(vol)) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n = 18; 59 to 75 years). RESULTS: We observed that the cognitive response to galantamine, more specifically the attention‐dependent filtering performance in a delayed match‐to‐sample working memory task, correlated with BF(vol): Only participants with high BF(vol) showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process. DISCUSSION: Future studies need to assess whether BF(vol) may serve as a predictor of the galantamine response in AD patients, too. |
format | Online Article Text |
id | pubmed-8020325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80203252021-04-08 Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study Müller, Patrick Vellage, Anne‐Katrin Schmicker, Marlen Menze, Inga Grothe, Michel J. Teipel, Stefan J. Müller, Notger G. Alzheimers Dement (N Y) Research Articles INTRODUCTION: Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors. METHODS: Here we investigate structural magnetic resonance imaging of the basal forebrain cholinergic system volume (BF(vol)) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n = 18; 59 to 75 years). RESULTS: We observed that the cognitive response to galantamine, more specifically the attention‐dependent filtering performance in a delayed match‐to‐sample working memory task, correlated with BF(vol): Only participants with high BF(vol) showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process. DISCUSSION: Future studies need to assess whether BF(vol) may serve as a predictor of the galantamine response in AD patients, too. John Wiley and Sons Inc. 2021-04-05 /pmc/articles/PMC8020325/ /pubmed/33842683 http://dx.doi.org/10.1002/trc2.12153 Text en © 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Müller, Patrick Vellage, Anne‐Katrin Schmicker, Marlen Menze, Inga Grothe, Michel J. Teipel, Stefan J. Müller, Notger G. Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study |
title | Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study |
title_full | Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study |
title_fullStr | Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study |
title_full_unstemmed | Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study |
title_short | Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study |
title_sort | structural mri of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—a randomized controlled double‐blinded crossover study |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020325/ https://www.ncbi.nlm.nih.gov/pubmed/33842683 http://dx.doi.org/10.1002/trc2.12153 |
work_keys_str_mv | AT mullerpatrick structuralmriofthebasalforebrainaspredictorofcognitiveresponsetogalantamineinhealthyolderadultsarandomizedcontrolleddoubleblindedcrossoverstudy AT vellageannekatrin structuralmriofthebasalforebrainaspredictorofcognitiveresponsetogalantamineinhealthyolderadultsarandomizedcontrolleddoubleblindedcrossoverstudy AT schmickermarlen structuralmriofthebasalforebrainaspredictorofcognitiveresponsetogalantamineinhealthyolderadultsarandomizedcontrolleddoubleblindedcrossoverstudy AT menzeinga structuralmriofthebasalforebrainaspredictorofcognitiveresponsetogalantamineinhealthyolderadultsarandomizedcontrolleddoubleblindedcrossoverstudy AT grothemichelj structuralmriofthebasalforebrainaspredictorofcognitiveresponsetogalantamineinhealthyolderadultsarandomizedcontrolleddoubleblindedcrossoverstudy AT teipelstefanj structuralmriofthebasalforebrainaspredictorofcognitiveresponsetogalantamineinhealthyolderadultsarandomizedcontrolleddoubleblindedcrossoverstudy AT mullernotgerg structuralmriofthebasalforebrainaspredictorofcognitiveresponsetogalantamineinhealthyolderadultsarandomizedcontrolleddoubleblindedcrossoverstudy |