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Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection

PURPOSE: The aim of the study was to investigate the association between serum 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection and parameters of immune function and clinical outcomes. METHODS: Fifty-six patients, who were admitted to the emergency clinic and diagnosed...

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Autores principales: Ünsal, Y. A., Gül, Ö. Ö., Cander, S., Ersoy, C., Aydemir, E., Ateş, C., Uzun, Z., Armağan, E., Ünsal, O., Ertürk, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020370/
https://www.ncbi.nlm.nih.gov/pubmed/33818731
http://dx.doi.org/10.1007/s40618-021-01566-9
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author Ünsal, Y. A.
Gül, Ö. Ö.
Cander, S.
Ersoy, C.
Aydemir, E.
Ateş, C.
Uzun, Z.
Armağan, E.
Ünsal, O.
Ertürk, E.
author_facet Ünsal, Y. A.
Gül, Ö. Ö.
Cander, S.
Ersoy, C.
Aydemir, E.
Ateş, C.
Uzun, Z.
Armağan, E.
Ünsal, O.
Ertürk, E.
author_sort Ünsal, Y. A.
collection PubMed
description PURPOSE: The aim of the study was to investigate the association between serum 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection and parameters of immune function and clinical outcomes. METHODS: Fifty-six patients, who were admitted to the emergency clinic and diagnosed with COVID–19 infection, were included in the study. Data on clinical characteristics, inflammatory parameters and vitamin D status were recorded for each patient. All the participants had data on 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection. RESULTS: The patients were stratified as those with vitamin D status less than 20 ng/mL and higher than 20 ng/mL. A group with vitamin D status less than 20 ng/mL had lower lymphocyte counts and lower haemoglobin levels that was statistically significant (respectively; p = 0.021, p = 0.035). Higher C-reactive protein (CRP) levels were seen in the vitamin D–deficient group (p = 0.013). It was observed that vitamin D status of the patients who required oxygen therapy were lower than those who did not require oxygen therapy, not statistically significant (p = 0.05). Patients who did not use vitamin D supplementation within 6 months prior to COVID-19 infection had more likely to be diagnosed with pneumonia (p = 0.004). CONCLUSION: Cases with lower vitamin D status had increased inflammatory markers and worse clinical outcomes than patients with higher vitamin D status. This study suggests that vitamin D status can be used as a prognostic factor in COVID-19 patients, and vitamin D supplementation can be recommended to improve the clinical outcomes in COVID-19 infection.
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spelling pubmed-80203702021-04-06 Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection Ünsal, Y. A. Gül, Ö. Ö. Cander, S. Ersoy, C. Aydemir, E. Ateş, C. Uzun, Z. Armağan, E. Ünsal, O. Ertürk, E. J Endocrinol Invest Original Article PURPOSE: The aim of the study was to investigate the association between serum 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection and parameters of immune function and clinical outcomes. METHODS: Fifty-six patients, who were admitted to the emergency clinic and diagnosed with COVID–19 infection, were included in the study. Data on clinical characteristics, inflammatory parameters and vitamin D status were recorded for each patient. All the participants had data on 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection. RESULTS: The patients were stratified as those with vitamin D status less than 20 ng/mL and higher than 20 ng/mL. A group with vitamin D status less than 20 ng/mL had lower lymphocyte counts and lower haemoglobin levels that was statistically significant (respectively; p = 0.021, p = 0.035). Higher C-reactive protein (CRP) levels were seen in the vitamin D–deficient group (p = 0.013). It was observed that vitamin D status of the patients who required oxygen therapy were lower than those who did not require oxygen therapy, not statistically significant (p = 0.05). Patients who did not use vitamin D supplementation within 6 months prior to COVID-19 infection had more likely to be diagnosed with pneumonia (p = 0.004). CONCLUSION: Cases with lower vitamin D status had increased inflammatory markers and worse clinical outcomes than patients with higher vitamin D status. This study suggests that vitamin D status can be used as a prognostic factor in COVID-19 patients, and vitamin D supplementation can be recommended to improve the clinical outcomes in COVID-19 infection. Springer International Publishing 2021-04-05 2021 /pmc/articles/PMC8020370/ /pubmed/33818731 http://dx.doi.org/10.1007/s40618-021-01566-9 Text en © Italian Society of Endocrinology (SIE) 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Ünsal, Y. A.
Gül, Ö. Ö.
Cander, S.
Ersoy, C.
Aydemir, E.
Ateş, C.
Uzun, Z.
Armağan, E.
Ünsal, O.
Ertürk, E.
Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection
title Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection
title_full Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection
title_fullStr Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection
title_full_unstemmed Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection
title_short Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection
title_sort retrospective analysis of vitamin d status on ınflammatory markers and course of the disease in patients with covid-19 infection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020370/
https://www.ncbi.nlm.nih.gov/pubmed/33818731
http://dx.doi.org/10.1007/s40618-021-01566-9
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