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Modeling of COVID-19 with limited public health resources: a comparative study of three most affected countries

COVID-19 has become a deadly pandemic in the recent times claiming millions of lives worldwide in a grievous manner. Most of the countries in the world have limited number of medical resources (hospitals, beds, ventilators, etc.), and in the case of large outbreak, it becomes very difficult to provi...

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Autores principales: Srivastav, Akhil Kumar, Ghosh, Mini, Bandekar, Shraddha Ramdas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020377/
https://www.ncbi.nlm.nih.gov/pubmed/33842186
http://dx.doi.org/10.1140/epjp/s13360-021-01333-y
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author Srivastav, Akhil Kumar
Ghosh, Mini
Bandekar, Shraddha Ramdas
author_facet Srivastav, Akhil Kumar
Ghosh, Mini
Bandekar, Shraddha Ramdas
author_sort Srivastav, Akhil Kumar
collection PubMed
description COVID-19 has become a deadly pandemic in the recent times claiming millions of lives worldwide in a grievous manner. Most of the countries in the world have limited number of medical resources (hospitals, beds, ventilators, etc.), and in the case of large outbreak, it becomes very difficult to provide treatment to every infected individual. In this study, we propound a mathematical model where we classify the infected into two subcategories—asymptomatic and symptomatic. This model further accounts for the effect of limited medical resource for infected people and using face masks in combating the pandemic. Focusing on these aspects, we analyze the model and exploit the available data for assessing the pattern in three most affected countries, namely USA, India and Brazil. The developed model is calibrated to fit data for these three countries and estimate the transmission rate of symptomatic, asymptomatic individuals. The rate at which the individuals who are quarantined recover is estimated as well. Along with these estimations, a comparative study based on the basic reproduction number estimated for the three countries is presented. Standard methods of sensitivity analysis are performed to analyze the ways in which basic reproduction number is impacted upon due to changes in different parameters of the model. Further, we obtain disease-free equilibrium and endemic equilibrium of the model. It is observed that backward bifurcation occurs if the capacity of treatment is small and bistable equilibria are shown that makes the system more sensitive to the initial conditions. Sufficient conditions for the local asymptomatic stability of the endemic equilibrium and disease-free equilibrium of the system are obtained. The results of this study imply that to curb the severity of the increasing cases of the disease in these countries, effective strategies to control disease spread should be implemented so that the basic reproduction number can be decreased below the threshold value which is certainly less than unity. The use of protective masks in public is shown to be an important preventive measure to lower disease transmission rate. Also, the quantity of medical resources should increase so that every infected person can get better treatment.
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spelling pubmed-80203772021-04-06 Modeling of COVID-19 with limited public health resources: a comparative study of three most affected countries Srivastav, Akhil Kumar Ghosh, Mini Bandekar, Shraddha Ramdas Eur Phys J Plus Regular Article COVID-19 has become a deadly pandemic in the recent times claiming millions of lives worldwide in a grievous manner. Most of the countries in the world have limited number of medical resources (hospitals, beds, ventilators, etc.), and in the case of large outbreak, it becomes very difficult to provide treatment to every infected individual. In this study, we propound a mathematical model where we classify the infected into two subcategories—asymptomatic and symptomatic. This model further accounts for the effect of limited medical resource for infected people and using face masks in combating the pandemic. Focusing on these aspects, we analyze the model and exploit the available data for assessing the pattern in three most affected countries, namely USA, India and Brazil. The developed model is calibrated to fit data for these three countries and estimate the transmission rate of symptomatic, asymptomatic individuals. The rate at which the individuals who are quarantined recover is estimated as well. Along with these estimations, a comparative study based on the basic reproduction number estimated for the three countries is presented. Standard methods of sensitivity analysis are performed to analyze the ways in which basic reproduction number is impacted upon due to changes in different parameters of the model. Further, we obtain disease-free equilibrium and endemic equilibrium of the model. It is observed that backward bifurcation occurs if the capacity of treatment is small and bistable equilibria are shown that makes the system more sensitive to the initial conditions. Sufficient conditions for the local asymptomatic stability of the endemic equilibrium and disease-free equilibrium of the system are obtained. The results of this study imply that to curb the severity of the increasing cases of the disease in these countries, effective strategies to control disease spread should be implemented so that the basic reproduction number can be decreased below the threshold value which is certainly less than unity. The use of protective masks in public is shown to be an important preventive measure to lower disease transmission rate. Also, the quantity of medical resources should increase so that every infected person can get better treatment. Springer Berlin Heidelberg 2021-04-05 2021 /pmc/articles/PMC8020377/ /pubmed/33842186 http://dx.doi.org/10.1140/epjp/s13360-021-01333-y Text en © The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Regular Article
Srivastav, Akhil Kumar
Ghosh, Mini
Bandekar, Shraddha Ramdas
Modeling of COVID-19 with limited public health resources: a comparative study of three most affected countries
title Modeling of COVID-19 with limited public health resources: a comparative study of three most affected countries
title_full Modeling of COVID-19 with limited public health resources: a comparative study of three most affected countries
title_fullStr Modeling of COVID-19 with limited public health resources: a comparative study of three most affected countries
title_full_unstemmed Modeling of COVID-19 with limited public health resources: a comparative study of three most affected countries
title_short Modeling of COVID-19 with limited public health resources: a comparative study of three most affected countries
title_sort modeling of covid-19 with limited public health resources: a comparative study of three most affected countries
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020377/
https://www.ncbi.nlm.nih.gov/pubmed/33842186
http://dx.doi.org/10.1140/epjp/s13360-021-01333-y
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