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Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation

The coronavirus disease, 2019 (COVID-19), has spread rapidly around the world and become a major public health problem facing the world. Traditional Chinese medicine (TCM) has been fully committed to treat COVID-19 in China. It improved the clinical symptoms of patients and reduced the mortality rat...

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Autores principales: Ma, Le-Le, Liu, Hui-Min, Luo, Chuan-Hong, He, Ya-Nan, Wang, Fang, Huang, Hao-Zhou, Han, Li, Yang, Ming, Xu, Run-Chun, Zhang, Ding-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020597/
https://www.ncbi.nlm.nih.gov/pubmed/33828481
http://dx.doi.org/10.3389/fphar.2021.583279
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author Ma, Le-Le
Liu, Hui-Min
Luo, Chuan-Hong
He, Ya-Nan
Wang, Fang
Huang, Hao-Zhou
Han, Li
Yang, Ming
Xu, Run-Chun
Zhang, Ding-Kun
author_facet Ma, Le-Le
Liu, Hui-Min
Luo, Chuan-Hong
He, Ya-Nan
Wang, Fang
Huang, Hao-Zhou
Han, Li
Yang, Ming
Xu, Run-Chun
Zhang, Ding-Kun
author_sort Ma, Le-Le
collection PubMed
description The coronavirus disease, 2019 (COVID-19), has spread rapidly around the world and become a major public health problem facing the world. Traditional Chinese medicine (TCM) has been fully committed to treat COVID-19 in China. It improved the clinical symptoms of patients and reduced the mortality rate. In light of the fever was identified as one of leading clinical features of COVID-19, this paper will first analyze the material basis of fever, including pyrogenic cytokines and a variety of the mediators of fever. Then the humoral and neural pathways of fever signal transmission will be described. The scattered evidences about fever recorded in recent years are connected in series. On this basis, the understanding of fever is further deepened from the aspects of pathology and physiology. Finally, combining with the chemical composition and pharmacological action of available TCM, we analyzed the mechanisms of TCMs to play the antipyretic effect through multiple ways. So as to further provide the basis for the research of antipyretic compound preparations of TCMs and explore the potential medicines for the prevention and treatment of COVID-19.
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spelling pubmed-80205972021-04-06 Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation Ma, Le-Le Liu, Hui-Min Luo, Chuan-Hong He, Ya-Nan Wang, Fang Huang, Hao-Zhou Han, Li Yang, Ming Xu, Run-Chun Zhang, Ding-Kun Front Pharmacol Pharmacology The coronavirus disease, 2019 (COVID-19), has spread rapidly around the world and become a major public health problem facing the world. Traditional Chinese medicine (TCM) has been fully committed to treat COVID-19 in China. It improved the clinical symptoms of patients and reduced the mortality rate. In light of the fever was identified as one of leading clinical features of COVID-19, this paper will first analyze the material basis of fever, including pyrogenic cytokines and a variety of the mediators of fever. Then the humoral and neural pathways of fever signal transmission will be described. The scattered evidences about fever recorded in recent years are connected in series. On this basis, the understanding of fever is further deepened from the aspects of pathology and physiology. Finally, combining with the chemical composition and pharmacological action of available TCM, we analyzed the mechanisms of TCMs to play the antipyretic effect through multiple ways. So as to further provide the basis for the research of antipyretic compound preparations of TCMs and explore the potential medicines for the prevention and treatment of COVID-19. Frontiers Media S.A. 2021-03-22 /pmc/articles/PMC8020597/ /pubmed/33828481 http://dx.doi.org/10.3389/fphar.2021.583279 Text en Copyright © 2021 Ma, Liu, Luo, He, Wang, Huang, Han, Yang, Xu and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ma, Le-Le
Liu, Hui-Min
Luo, Chuan-Hong
He, Ya-Nan
Wang, Fang
Huang, Hao-Zhou
Han, Li
Yang, Ming
Xu, Run-Chun
Zhang, Ding-Kun
Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation
title Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation
title_full Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation
title_fullStr Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation
title_full_unstemmed Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation
title_short Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation
title_sort fever and antipyretic supported by traditional chinese medicine: a multi-pathway regulation
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020597/
https://www.ncbi.nlm.nih.gov/pubmed/33828481
http://dx.doi.org/10.3389/fphar.2021.583279
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