Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage

Genetic variation within the factor H–related (FHR) genes is associated with the complement-mediated kidney disease, C3 glomerulopathy (C3G). There is no definitive treatment for C3G, and a significant proportion of patients develop end-stage renal disease. The prototypical example is CFHR5 nephropa...

Descripción completa

Detalles Bibliográficos
Autores principales: Malik, Talat H., Gitterman, Daniel P., Lavin, Deborah P., Lomax-Browne, Hannah J., Hiemeyer, E. Christina, Moran, Linda B., Boroviak, Katharina, Cook, H. Terence, Gilmore, Alyssa C., Mandwie, Mawj, Ahmad, Amina, Alexander, Ian E., Logan, Grant J., Marchbank, Kevin J., Bradley, Allan, Pickering, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020653/
https://www.ncbi.nlm.nih.gov/pubmed/33753502
http://dx.doi.org/10.1073/pnas.2022722118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020653/
https://www.ncbi.nlm.nih.gov/pubmed/33753502
http://dx.doi.org/10.1073/pnas.2022722118

Ejemplares similares