GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice

The homeostasis of protein palmitoylation and depalmitoylation is essential for proper physiological functions in various tissues, in particular the central nervous system (CNS). The dysfunction of PPT1 (PPT1-KI, infantile neuronal ceroid lipofuscinosis [INCL] mouse model), which catalyze the depalm...

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Detalles Bibliográficos
Autores principales: Yuan, Wei, Lu, Liaoxun, Rao, Muding, Huang, Yang, Liu, Chun-e, Liu, Shuang, Zhao, Yue, Liu, Huicong, Zhu, Jiangli, Chao, Tianzhu, Wu, Can, Ren, Junyan, Lv, Luxian, Li, Wenqiang, Qi, Shiqian, Liang, Yinming, Yue, Shijing, Gao, Jian, Zhang, Zhongjian, Kong, Eryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020761/
https://www.ncbi.nlm.nih.gov/pubmed/33753498
http://dx.doi.org/10.1073/pnas.2022261118

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