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Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids

The ability of tau aggregates to recruit and misfold monomeric tau and propagate across brain regions has been studied extensively and is now recognized as a critical pathological step in Alzheimer’s disease (AD) and other tauopathies. Recent evidence suggests that the detection of tau seeds in huma...

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Autores principales: Lathuiliere, Aurelien, Hyman, Bradley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020844/
https://www.ncbi.nlm.nih.gov/pubmed/33828458
http://dx.doi.org/10.3389/fnins.2021.654176
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author Lathuiliere, Aurelien
Hyman, Bradley T.
author_facet Lathuiliere, Aurelien
Hyman, Bradley T.
author_sort Lathuiliere, Aurelien
collection PubMed
description The ability of tau aggregates to recruit and misfold monomeric tau and propagate across brain regions has been studied extensively and is now recognized as a critical pathological step in Alzheimer’s disease (AD) and other tauopathies. Recent evidence suggests that the detection of tau seeds in human samples may be relevant and correlate with clinical data. Here, we review the available methods for the measurement of such tau seeds, their limitations and their potential implementation for the development of the next-generation biomarkers.
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spelling pubmed-80208442021-04-06 Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids Lathuiliere, Aurelien Hyman, Bradley T. Front Neurosci Neuroscience The ability of tau aggregates to recruit and misfold monomeric tau and propagate across brain regions has been studied extensively and is now recognized as a critical pathological step in Alzheimer’s disease (AD) and other tauopathies. Recent evidence suggests that the detection of tau seeds in human samples may be relevant and correlate with clinical data. Here, we review the available methods for the measurement of such tau seeds, their limitations and their potential implementation for the development of the next-generation biomarkers. Frontiers Media S.A. 2021-03-19 /pmc/articles/PMC8020844/ /pubmed/33828458 http://dx.doi.org/10.3389/fnins.2021.654176 Text en Copyright © 2021 Lathuiliere and Hyman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lathuiliere, Aurelien
Hyman, Bradley T.
Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids
title Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids
title_full Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids
title_fullStr Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids
title_full_unstemmed Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids
title_short Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids
title_sort quantitative methods for the detection of tau seeding activity in human biofluids
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020844/
https://www.ncbi.nlm.nih.gov/pubmed/33828458
http://dx.doi.org/10.3389/fnins.2021.654176
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