MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

Oligodendrocytes (OLs) are important for myelination and shuttling energy metabolites lactate and pyruvate toward axons through their expression of monocarboxylate transporter 1 (MCT1). Recent studies suggest that loss of OL MCT1 causes axonal degeneration. However, it is unknown how widespread and...

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Detalles Bibliográficos
Autores principales: Philips, Thomas, Mironova, Yevgeniya A., Jouroukhin, Yan, Chew, Jeannie, Vidensky, Svetlana, Farah, Mohamed H., Pletnikov, Mikhail V., Bergles, Dwight E., Morrison, Brett M., Rothstein, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020895/
https://www.ncbi.nlm.nih.gov/pubmed/33440165
http://dx.doi.org/10.1016/j.celrep.2020.108610

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