Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques

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Severe COVID-19 has been associated with T cell lymphopenia(1,2), but no causal effect of T cell deficiency on disease severity has been established. To investigate the specific role of T cells in recovery from SARS-CoV-2 infections we studied rhesus macaques that were depleted of either CD4(+), CD8...

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Detalles Bibliográficos
Autores principales: Hasenkrug, Kim J., Feldmann, Friederike, Myers, Lara, Santiago, Mario L., Guo, Kejun, Barrett, Bradley S., Mickens, Kaylee L., Carmody, Aaron, Okumura, Atsushi, Rao, Deepashri, Collins, Madison M., Messer, Ronald J., Lovaglio, Jamie, Shaia, Carl, Rosenke, Rebecca, van Doremalen, Neeltje, Clancy, Chad, Saturday, Greg, Hanley, Patrick, Smith, Brian, Meade-White, Kimberly, Shupert, W. Lesley, Hawman, David W., Feldmann, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020972/
https://www.ncbi.nlm.nih.gov/pubmed/33821272
http://dx.doi.org/10.1101/2021.04.02.438262
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