Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

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High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a 3’-to-5’ exoribonuclease (ExoN) in non-structural protein 14 (nsp14), which excises nucleotides including antiviral drugs mis-incorporated by the low-fidelity viral RNA-dependent RNA polymerase (RdRp) and has...

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Detalles Bibliográficos
Autores principales: Moeller, Nicholas H., Shi, Ke, Demir, Özlem, Banerjee, Surajit, Yin, Lulu, Belica, Christopher, Durfee, Cameron, Amaro, Rommie E., Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020977/
https://www.ncbi.nlm.nih.gov/pubmed/33821277
http://dx.doi.org/10.1101/2021.04.02.438274

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