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Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN
High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a 3’-to-5’ exoribonuclease (ExoN) in non-structural protein 14 (nsp14), which excises nucleotides including antiviral drugs mis-incorporated by the low-fidelity viral RNA-dependent RNA polymerase (RdRp) and has...
Autores principales: | Moeller, Nicholas H., Shi, Ke, Demir, Özlem, Banerjee, Surajit, Yin, Lulu, Belica, Christopher, Durfee, Cameron, Amaro, Rommie E., Aihara, Hideki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020977/ https://www.ncbi.nlm.nih.gov/pubmed/33821277 http://dx.doi.org/10.1101/2021.04.02.438274 |
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