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Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets

While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing COVID-19 manifestations in patients of different ages, t...

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Autores principales: Kim, Young-Il, Yu, Kwang-Min, Koh, June-Young, Kim, Eun-Ha, Kim, Se-Mi, Kim, Eun Ji, Casel, Mark Anthony, Rollon, Rare, Jang, Seung-Gyu, Song, Min-Suk, Park, Su-Jin, Jeong, Hye Won, Kim, Eung-Gook, Lee, Ok-Jun, Choi, Younho, Lee, Shin-Ae, Park, Su-Hyung, Jung, Jae U., Choi, Young Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020987/
https://www.ncbi.nlm.nih.gov/pubmed/33821260
http://dx.doi.org/10.21203/rs.3.rs-131380/v2
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author Kim, Young-Il
Yu, Kwang-Min
Koh, June-Young
Kim, Eun-Ha
Kim, Se-Mi
Kim, Eun Ji
Casel, Mark Anthony
Rollon, Rare
Jang, Seung-Gyu
Song, Min-Suk
Park, Su-Jin
Jeong, Hye Won
Kim, Eung-Gook
Lee, Ok-Jun
Choi, Younho
Lee, Shin-Ae
Park, Su-Hyung
Jung, Jae U.
Choi, Young Ki
author_facet Kim, Young-Il
Yu, Kwang-Min
Koh, June-Young
Kim, Eun-Ha
Kim, Se-Mi
Kim, Eun Ji
Casel, Mark Anthony
Rollon, Rare
Jang, Seung-Gyu
Song, Min-Suk
Park, Su-Jin
Jeong, Hye Won
Kim, Eung-Gook
Lee, Ok-Jun
Choi, Younho
Lee, Shin-Ae
Park, Su-Hyung
Jung, Jae U.
Choi, Young Ki
author_sort Kim, Young-Il
collection PubMed
description While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing COVID-19 manifestations in patients of different ages, three age groups of ferrets were infected with SARS-CoV-2. Although SARS-CoV-2 was isolated from all ferrets regardless of age, aged ferrets (≥ 3 years old) showed higher viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration and clinical symptoms compared to juvenile (≤ 6 months) and young adult (1–2 years) groups. Transcriptome analysis of aged ferret lungs revealed strong enrichment of gene sets related to type I interferon, activated T cells, and M1 macrophage responses, mimicking the gene expression profile of severe COVID-19 patients. Thus, SARS-CoV-2-infected aged ferrets highly recapitulate COVID-19 patients with severe symptoms and are useful for understanding age-associated infection, transmission, and pathogenesis of SARS-CoV-2.
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spelling pubmed-80209872021-04-06 Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets Kim, Young-Il Yu, Kwang-Min Koh, June-Young Kim, Eun-Ha Kim, Se-Mi Kim, Eun Ji Casel, Mark Anthony Rollon, Rare Jang, Seung-Gyu Song, Min-Suk Park, Su-Jin Jeong, Hye Won Kim, Eung-Gook Lee, Ok-Jun Choi, Younho Lee, Shin-Ae Park, Su-Hyung Jung, Jae U. Choi, Young Ki Res Sq Article While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing COVID-19 manifestations in patients of different ages, three age groups of ferrets were infected with SARS-CoV-2. Although SARS-CoV-2 was isolated from all ferrets regardless of age, aged ferrets (≥ 3 years old) showed higher viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration and clinical symptoms compared to juvenile (≤ 6 months) and young adult (1–2 years) groups. Transcriptome analysis of aged ferret lungs revealed strong enrichment of gene sets related to type I interferon, activated T cells, and M1 macrophage responses, mimicking the gene expression profile of severe COVID-19 patients. Thus, SARS-CoV-2-infected aged ferrets highly recapitulate COVID-19 patients with severe symptoms and are useful for understanding age-associated infection, transmission, and pathogenesis of SARS-CoV-2. American Journal Experts 2021-03-29 /pmc/articles/PMC8020987/ /pubmed/33821260 http://dx.doi.org/10.21203/rs.3.rs-131380/v2 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Kim, Young-Il
Yu, Kwang-Min
Koh, June-Young
Kim, Eun-Ha
Kim, Se-Mi
Kim, Eun Ji
Casel, Mark Anthony
Rollon, Rare
Jang, Seung-Gyu
Song, Min-Suk
Park, Su-Jin
Jeong, Hye Won
Kim, Eung-Gook
Lee, Ok-Jun
Choi, Younho
Lee, Shin-Ae
Park, Su-Hyung
Jung, Jae U.
Choi, Young Ki
Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
title Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
title_full Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
title_fullStr Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
title_full_unstemmed Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
title_short Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
title_sort age-dependent pathogenic characteristics of sars-cov-2 infection in ferrets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020987/
https://www.ncbi.nlm.nih.gov/pubmed/33821260
http://dx.doi.org/10.21203/rs.3.rs-131380/v2
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