Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1

Altered expression of the translation factor eIF3e is associated with breast cancer occurrence. We have previously shown that eIF3e deficiency leads to an impaired DNA damage response with a marked decrease in DNA repair by homologous recombination. Here, we explored the possibility to exploit this...

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Detalles Bibliográficos
Autores principales: Morris, Christelle, Durand, Sébastien, Jalinot, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021025/
https://www.ncbi.nlm.nih.gov/pubmed/33868586
http://dx.doi.org/10.18632/oncotarget.27923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021025/
https://www.ncbi.nlm.nih.gov/pubmed/33868586
http://dx.doi.org/10.18632/oncotarget.27923

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