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Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts

Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regulating sepsis mortality. Because TIGIT is significantly upreg...

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Detalles Bibliográficos
Autores principales:	Sun, Yini, Anyalebechi, Jerome C., Sun, He, Yumoto, Tetsuya, Xue, Ming, Liu, Danya, Liang, Zhe, Coopersmith, Craig M., Ford, Mandy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021109/ https://www.ncbi.nlm.nih.gov/pubmed/33682797 http://dx.doi.org/10.1172/jci.insight.141245

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