Reversible cardiac disease features in an inducible CUG repeat RNA–expressing mouse model of myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is caused by a CTG repeat expansion in the DMPK gene. Expression of pathogenic expanded CUG repeat (CUGexp) RNA causes multisystemic disease by perturbing the functions of RNA-binding proteins, resulting in expression of fetal protein isoforms in adult tissues. Cardia...

Descripción completa

Detalles Bibliográficos
Autores principales: Rao, Ashish N., Campbell, Hannah M., Guan, Xiangnan, Word, Tarah A., Wehrens, Xander H.T., Xia, Zheng, Cooper, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021116/
https://www.ncbi.nlm.nih.gov/pubmed/33497365
http://dx.doi.org/10.1172/jci.insight.143465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021116/
https://www.ncbi.nlm.nih.gov/pubmed/33497365
http://dx.doi.org/10.1172/jci.insight.143465

Ejemplares similares