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Reversible cardiac disease features in an inducible CUG repeat RNA–expressing mouse model of myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is caused by a CTG repeat expansion in the DMPK gene. Expression of pathogenic expanded CUG repeat (CUGexp) RNA causes multisystemic disease by perturbing the functions of RNA-binding proteins, resulting in expression of fetal protein isoforms in adult tissues. Cardia...

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Detalles Bibliográficos
Autores principales:	Rao, Ashish N., Campbell, Hannah M., Guan, Xiangnan, Word, Tarah A., Wehrens, Xander H.T., Xia, Zheng, Cooper, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021116/ https://www.ncbi.nlm.nih.gov/pubmed/33497365 http://dx.doi.org/10.1172/jci.insight.143465

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