Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

OBJECTIVES: Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continue at pace. Here, we describe rational antigen design through to manufacturability and vaccine efficacy of a prefusion‐stabilised spike (S) protein, Sclamp, in comb...

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Detalles Bibliográficos
Autores principales: Watterson, Daniel, Wijesundara, Danushka K, Modhiran, Naphak, Mordant, Francesca L, Li, Zheyi, Avumegah, Michael S, McMillan, Christopher LD, Lackenby, Julia, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Cheung, Stacey TM, Bibby, Summa, Daleris, Mallory, Hoger, Kym, Gillard, Marianne, Radunz, Eve, Jones, Martina L, Hughes, Karen, Hughes, Ben, Goh, Justin, Edwards, David, Scoble, Judith, Pearce, Lesley, Kowalczyk, Lukasz, Phan, Tram, La, Mylinh, Lu, Louis, Pham, Tam, Zhou, Qi, Brockman, David A, Morgan, Sherry J, Lau, Cora, Tran, Mai H, Tapley, Peter, Villalón‐Letelier, Fernando, Barnes, James, Young, Andrew, Jaberolansar, Noushin, Scott, Connor AP, Isaacs, Ariel, Amarilla, Alberto A, Khromykh, Alexander A, van den Brand, Judith MA, Reading, Patrick C, Ranasinghe, Charani, Subbarao, Kanta, Munro, Trent P, Young, Paul R, Chappell, Keith J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021130/
https://www.ncbi.nlm.nih.gov/pubmed/33841880
http://dx.doi.org/10.1002/cti2.1269

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