Cargando…

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery

Traumatic spinal cord injury (SCI) is a devastating neurological condition that involves both primary and secondary tissue loss. Various cytotoxic events including hypoxia, hemorrhage and blood lysis, bioenergetic failure, oxidative stress, endoplasmic reticulum (ER) stress, and neuroinflammation co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, George Z., Saraswat Ohri, Sujata, Khattar, Nicolas K., Listerman, Adam W., Doyle, Catherine H., Andres, Kariena R., Karuppagounder, Saravanan S., Ratan, Rajiv R., Whittemore, Scott R., Hetman, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021188/ https://www.ncbi.nlm.nih.gov/pubmed/33819286 http://dx.doi.org/10.1371/journal.pone.0249591

Ejemplares similares

Improved locomotor recovery after contusive spinal cord injury in Bmal1(−/−) mice is associated with protection of the blood spinal cord barrier
por: Slomnicki, Lukasz P., et al.
Publicado: (2020)

Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day
por: Slomnicki, Lukasz P., et al.
Publicado: (2021)

Inhibition of GADD34, the Stress-Inducible Regulatory Subunit of the Endoplasmic Reticulum Stress Response, Does Not Enhance Functional Recovery after Spinal Cord Injury
por: Saraswat Ohri, Sujata, et al.
Publicado: (2014)

Antioxidant Protection of NADPH-Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione
por: Kilanczyk, Ewa, et al.
Publicado: (2016)

Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3
por: Gao, Yonglin, et al.
Publicado: (2023)

Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer
por: Rawluszko, Agnieszka A, et al.
Publicado: (2013)

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis
por: Neitemeier, S, et al.
Publicado: (2016)

The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury
por: Whittemore, Scott R., et al.
Publicado: (2022)

Molecular Characterization and Response of Prolyl Hydroxylase Domain (PHD) Genes to Hypoxia Stress in Hypophthalmichthys molitrix
por: Li, Xiaohui, et al.
Publicado: (2022)

Enhanced oxidative phosphorylation, re-organized intracellular signaling, and epigenetic de-silencing as revealed by oligodendrocyte translatome analysis after contusive spinal cord injury
por: Forston, Michael D., et al.
Publicado: (2023)

Enhanced oxidative phosphorylation, re-organized intracellular signaling, and epigenetic de-silencing as revealed by oligodendrocyte translatome analysis after contusive spinal cord injury
por: Forston, Michael D., et al.
Publicado: (2023)

Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27
por: Högel, Heidi, et al.
Publicado: (2015)

Prolyl Hydroxylase PHD3 Enhances the Hypoxic Survival and G1 to S Transition of Carcinoma Cells
por: Högel, Heidi, et al.
Publicado: (2011)

Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition
por: Place, Trenton L., et al.
Publicado: (2013)

Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins
por: Wong, Samantha J., et al.
Publicado: (2021)

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility
por: Astuti, Dewi, et al.
Publicado: (2011)

Caloric restriction counteracts age-dependent changes in prolyl-4-hydroxylase domain (PHD) 3 expression
por: Rohrbach, Susanne, et al.
Publicado: (2008)

Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury
por: Fang, Yi, et al.
Publicado: (2016)

Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Regulates Chondrocyte Differentiation and Secondary Ossification in Mice
por: Cheng, Shaohong, et al.
Publicado: (2016)

mRNA overexpression of prolyl hydroxylase PHD3 is inversely related to nuclear grade in renal cell carcinoma
por: Kampantais, Spyridon, et al.
Publicado: (2020)

Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice
por: Thomas, Amandine, et al.
Publicado: (2016)

Computational analysis of prolyl hydroxylase domain-containing protein 2 (PHD2) mutations promoting polycythemia insurgence in humans
por: Minervini, Giovanni, et al.
Publicado: (2016)

HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
por: Miikkulainen, Petra, et al.
Publicado: (2017)

Lack of Skeletal Effects in Mice with Targeted Disruptionof Prolyl Hydroxylase Domain 1 (Phd1) Gene Expressed in Chondrocytes
por: Xing, Weirong, et al.
Publicado: (2022)

Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2
por: Hou, Peifeng, et al.
Publicado: (2014)

Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer
por: Kozlova, Nina, et al.
Publicado: (2016)

A computational evaluation of FDA medicines’ ability to inhibit hypoxia-inducible factor prolyl hydroxylase-2 (PHD-2) for acute respiratory distress syndrome
por: Chandrasekaran, Jaikanth, et al.
Publicado: (2022)

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors and Iron Metabolism
por: Ogawa, Chie, et al.
Publicado: (2023)

Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease
por: Lun, Jie, et al.
Publicado: (2023)

Gene Expression Levels of the Prolyl Hydroxylase Domain Proteins PHD1 and PHD2 but Not PHD3 Are Decreased in Primary Tumours and Correlate with Poor Prognosis of Patients with Surgically Resected Non-Small-Cell Lung Cancer
por: Koren, Ana, et al.
Publicado: (2021)

The role of HIF prolyl hydroxylases in tumour growth
por: Jokilehto, Terhi, et al.
Publicado: (2010)

Function and expression of prolyl hydroxylase 3 in cancers
por: Liu, Qiu-long, et al.
Publicado: (2013)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
por: Savyuk, Maria, et al.
Publicado: (2020)

Hypoxia-inducible factor prolyl hydroxylase inhibitors in kidney transplant recipients
por: Ogata, Masatomo, et al.
Publicado: (2022)

Bibliometric analysis of hypoxia inducible factor prolyl hydroxylase inhibitor in anemia
por: Zheng, Li, et al.
Publicado: (2022)

Gas tunnel engineering of prolyl hydroxylase reprograms hypoxia signaling in cells
por: Windsor, Peter, et al.
Publicado: (2023)

Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism
por: Yang, Ming, et al.
Publicado: (2014)

Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD)
por: Sayaf, Abrar Mohammad, et al.
Publicado: (2023)

Phase I Clinical Study of ZYAN1, A Novel Prolyl-Hydroxylase (PHD) Inhibitor to Evaluate the Safety, Tolerability, and Pharmacokinetics Following Oral Administration in Healthy Volunteers
por: Kansagra, Kevinkumar A., et al.
Publicado: (2017)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor
por: Kiriakidis, Serafim, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ckopohgnrmlpbor8tsvfkmekhi