Cargando…

Dexmedetomidine ameliorates lipopolysaccharide-induced acute lung injury by inhibiting the PI3K/Akt/FoxO1 signaling pathway

PURPOSE: Dexmedetomidine (DEX) has been associated with inflammation, oxidative stress, and apoptosis, but its effects on lipopolysaccharide (LPS)-induced lung injury remain uncertain. The present study explored the effects of DEX on LPS-induced lung injury and studied the possible molecular mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Haibin, Zhang, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021217/ https://www.ncbi.nlm.nih.gov/pubmed/33821300 http://dx.doi.org/10.1007/s00540-021-02909-9

Ejemplares similares

Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway
por: Dong, Hongquan, et al.
Publicado: (2014)

Low-dose lipopolysaccharide inhibits neuronal apoptosis induced by cerebral ischemia/reperfusion injury via the PI3K/Akt/FoxO1 signaling pathway in rats
por: He, Fan, et al.
Publicado: (2019)

Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway
por: Chen, Yuxi, et al.
Publicado: (2020)

Schisandrin Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating TLR-4 and Akt/FoxO1 Signaling Pathways
por: Sun, Kai, et al.
Publicado: (2018)

Effect of let-7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma
por: Li, Yuehua, et al.
Publicado: (2021)

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation
por: Cohen, Shenhav, et al.
Publicado: (2014)

Suppression of FoxO6 by lipopolysaccharide in aged rat liver
por: Kim, Dae Hyun, et al.
Publicado: (2015)

Cell type-specific regulation of CCN2 protein expression by PI3K–AKT–FoxO signaling
por: Samarin, Jana, et al.
Publicado: (2009)

Inhibition of PTEN Ameliorates Secondary Hippocampal Injury and Cognitive Deficits after Intracerebral Hemorrhage: Involvement of AKT/FoxO3a/ATG-Mediated Autophagy
por: Zhao, Manman, et al.
Publicado: (2021)

Pristimerin‐induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway
por: Yan, Fengxia, et al.
Publicado: (2020)

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway
por: Guo, Li-Ting, et al.
Publicado: (2019)

TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice
por: Wang, Yaping, et al.
Publicado: (2020)

Resveratrol inhibits bile acid‐induced gastric intestinal metaplasia via the PI3K/AKT/p‐FoxO4 signalling pathway
por: Lu, Wenquan, et al.
Publicado: (2020)

Mitochondrial Respiration Inhibition Suppresses Papillary Thyroid Carcinoma Via PI3K/Akt/FoxO1/Cyclin D1 Pathway
por: Chen, Bojie, et al.
Publicado: (2022)

Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway
por: Zhao, Yuan, et al.
Publicado: (2020)

Formononetin ameliorates muscle atrophy by regulating myostatin‐mediated PI3K/Akt/FoxO3a pathway and satellite cell function in chronic kidney disease
por: Liu, Lingyu, et al.
Publicado: (2021)

Hypoxia Enhances Chondrogenesis and Prevents Terminal Differentiation through PI3K/Akt/FoxO Dependent Anti-Apoptotic Effect
por: Lee, Hsieh-Hsing, et al.
Publicado: (2013)

Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway
por: Xiang, Ming, et al.
Publicado: (2022)

Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway
por: Yang, Cheng, et al.
Publicado: (2015)

Inhibition of PTEN Gene Expression by Small Interfering RNA on PI3K/Akt/FoxO3a Signaling Pathway in Human Nasopharyngeal Carcinoma
por: Yao, Liang Zhong, et al.
Publicado: (2020)

Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway
por: Alaaeldin, Rania, et al.
Publicado: (2021)

Tempol Attenuates Renal Fibrosis in Mice with Unilateral Ureteral Obstruction: The Role of PI3K-Akt-FoxO3a Signaling
por: Yoon, Hye Eun, et al.
Publicado: (2014)

Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice
por: Xu, Qinqin, et al.
Publicado: (2022)

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1–dependent manner
por: Pajvani, Utpal B., et al.
Publicado: (2011)

Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats
por: Chen, Yi-Nan, et al.
Publicado: (2020)

Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats
por: Li, Junrong, et al.
Publicado: (2020)

Osteopontin is linked with AKT, FoxO1, and myostatin in skeletal muscle cells
por: Nghiem, Peter P., et al.
Publicado: (2017)

Homocysteine promotes cardiac fibrosis by regulating the Akt/FoxO3 pathway
por: Shi, Ying, et al.
Publicado: (2021)

Association Study to Evaluate FoxO1 and FoxO3 Gene in CHD in Han Chinese
por: Zhao, Ying, et al.
Publicado: (2014)

Redox-Sensitive Up-Regulation of eNOS by Purple Grape Juice in Endothelial Cells: Role of PI3-Kinase/Akt, p38 MAPK, JNK, FoxO1 and FoxO3a
por: Alhosin, Mahmoud, et al.
Publicado: (2013)

CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway
por: Liu, Yunen, et al.
Publicado: (2019)

FoxO Proteins in the Nervous System
por: Maiese, Kenneth
Publicado: (2015)

LIPUS‐SCs‐Exo promotes peripheral nerve regeneration in cavernous nerve crush injury‐induced ED rats via PI3K/Akt/FoxO signaling pathway
por: Ye, Kun, et al.
Publicado: (2023)

Dihydromyricetin protects HUVECs of oxidative damage induced by sodium nitroprusside through activating PI3K/Akt/FoxO3a signalling pathway
por: Zhang, Xiaoying, et al.
Publicado: (2019)

Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway
por: Lei, Zhiqi, et al.
Publicado: (2023)

MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway
por: Liu, Feng, et al.
Publicado: (2019)

Adiponectin Reduces Embryonic Loss Rate and Ameliorates Trophoblast Apoptosis in Early Pregnancy of Mice with Polycystic Ovary Syndrome by Affecting the AMPK/PI3K/Akt/FoxO3a Signaling Pathway
por: Zhang, Wenqian, et al.
Publicado: (2020)

Luteolin loaded on zinc oxide nanoparticles ameliorates non-alcoholic fatty liver disease associated with insulin resistance in diabetic rats via regulation of PI3K/AKT/FoxO1 pathway
por: Ahmed, Esraa SA, et al.
Publicado: (2022)

Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction
por: Liu, Qun, et al.
Publicado: (2017)

rhKGF-2 Attenuates Smoke Inhalation Lung Injury of Rats via Activating PI3K/Akt/Nrf2 and Repressing FoxO1-NLRP3 Inflammasome
por: Fu, Zhonghua, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_shf2dr5c2sg6cgf8u9aaa8249s