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The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: A retrospective study

This study aimed to investigate the association between mean platelet volume (MPV) and metabolic syndrome (MetS) in patients with type 2 diabetes mellitus (T2DM). Data for 1240 patients with T2DM admitted to the Department of Endocrinology at the First Affiliated Hospital of Guangxi Medical Universi...

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Autores principales: Ding, Qinpei, Wang, Fangwei, Guo, Xintong, Liang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021380/
https://www.ncbi.nlm.nih.gov/pubmed/33787620
http://dx.doi.org/10.1097/MD.0000000000025303
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author Ding, Qinpei
Wang, Fangwei
Guo, Xintong
Liang, Min
author_facet Ding, Qinpei
Wang, Fangwei
Guo, Xintong
Liang, Min
author_sort Ding, Qinpei
collection PubMed
description This study aimed to investigate the association between mean platelet volume (MPV) and metabolic syndrome (MetS) in patients with type 2 diabetes mellitus (T2DM). Data for 1240 patients with T2DM admitted to the Department of Endocrinology at the First Affiliated Hospital of Guangxi Medical University between January 1, 2017 and June 1, 2020 were collected retrospectively via electronic medical records, including demographic information, complete blood count, lipid profile, and glucose metabolism indexes. MetS was defined according to the Chinese Diabetes Society. Among the 1240 patients enrolled, 873 (70.40%) had MetS. MPV was significantly higher in patients with MetS (P < .001). For individual MetS components, MPV was significantly higher in the presence of abdominal obesity (P = .013) and hypertriglyceridemia (P = .026), but did not differ in the presence of elevated blood pressure (P = .330) or low high-density lipoprotein cholesterol (P = .790). Moreover, MPV was independently associated with MetS after adjustment for sex, smoking, alcohol drinking, white blood cell count, fasting C-peptide, and body mass index (odds ratio 1.174, 95% confidence interval 1.059–1.302). The odds ratio for MetS in the highest tertile, compared with the lowest MPV tertile, was 1.724 (95% confidence interval 1.199–2.479, P for trend = .003) after multiple adjustment. In stratified analyses, the positive correlation of MPV with MetS was significant only in patients who were older, male, or overweight, or who had poor glycemic control. In conclusion, high MPV was positively associated with the presence of MetS in patients with T2DM, particularly older, male, or overweight patients, or those with poor glycemic control.
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spelling pubmed-80213802021-04-07 The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: A retrospective study Ding, Qinpei Wang, Fangwei Guo, Xintong Liang, Min Medicine (Baltimore) 4300 This study aimed to investigate the association between mean platelet volume (MPV) and metabolic syndrome (MetS) in patients with type 2 diabetes mellitus (T2DM). Data for 1240 patients with T2DM admitted to the Department of Endocrinology at the First Affiliated Hospital of Guangxi Medical University between January 1, 2017 and June 1, 2020 were collected retrospectively via electronic medical records, including demographic information, complete blood count, lipid profile, and glucose metabolism indexes. MetS was defined according to the Chinese Diabetes Society. Among the 1240 patients enrolled, 873 (70.40%) had MetS. MPV was significantly higher in patients with MetS (P < .001). For individual MetS components, MPV was significantly higher in the presence of abdominal obesity (P = .013) and hypertriglyceridemia (P = .026), but did not differ in the presence of elevated blood pressure (P = .330) or low high-density lipoprotein cholesterol (P = .790). Moreover, MPV was independently associated with MetS after adjustment for sex, smoking, alcohol drinking, white blood cell count, fasting C-peptide, and body mass index (odds ratio 1.174, 95% confidence interval 1.059–1.302). The odds ratio for MetS in the highest tertile, compared with the lowest MPV tertile, was 1.724 (95% confidence interval 1.199–2.479, P for trend = .003) after multiple adjustment. In stratified analyses, the positive correlation of MPV with MetS was significant only in patients who were older, male, or overweight, or who had poor glycemic control. In conclusion, high MPV was positively associated with the presence of MetS in patients with T2DM, particularly older, male, or overweight patients, or those with poor glycemic control. Lippincott Williams & Wilkins 2021-04-02 /pmc/articles/PMC8021380/ /pubmed/33787620 http://dx.doi.org/10.1097/MD.0000000000025303 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4300
Ding, Qinpei
Wang, Fangwei
Guo, Xintong
Liang, Min
The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: A retrospective study
title The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: A retrospective study
title_full The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: A retrospective study
title_fullStr The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: A retrospective study
title_full_unstemmed The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: A retrospective study
title_short The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: A retrospective study
title_sort relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: a retrospective study
topic 4300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021380/
https://www.ncbi.nlm.nih.gov/pubmed/33787620
http://dx.doi.org/10.1097/MD.0000000000025303
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