Cargando…

Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process

Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC–MS-based untargeted metabolomics to analyze plasma metabolic characteristics in...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Hong, Jin, Shengwei, Li, Ting, Ying, Weiyang, Ying, Binyu, Chen, Dong, Ning, Jie, Zheng, Chanfan, Li, Yuping, Li, Chen, Chen, Chengshui, Li, Xiaokun, Gao, Hongchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021501/
https://www.ncbi.nlm.nih.gov/pubmed/33841749
http://dx.doi.org/10.1016/j.csbj.2021.03.039
_version_ 1783674759451508736
author Zheng, Hong
Jin, Shengwei
Li, Ting
Ying, Weiyang
Ying, Binyu
Chen, Dong
Ning, Jie
Zheng, Chanfan
Li, Yuping
Li, Chen
Chen, Chengshui
Li, Xiaokun
Gao, Hongchang
author_facet Zheng, Hong
Jin, Shengwei
Li, Ting
Ying, Weiyang
Ying, Binyu
Chen, Dong
Ning, Jie
Zheng, Chanfan
Li, Yuping
Li, Chen
Chen, Chengshui
Li, Xiaokun
Gao, Hongchang
author_sort Zheng, Hong
collection PubMed
description Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC–MS-based untargeted metabolomics to analyze plasma metabolic characteristics in men and women with non-severe COVID-19 at both acute period and 30 days after discharge. The results demonstrate that metabolic alterations in plasma of COVID-19 patients during the recovery and rehabilitation process were presented in a sex specific manner. Overall, the levels of most metabolites were increased in COVID-19 patients after the cure relative to acute period. The major plasma metabolic changes were identified including fatty acids in men and glycerophosphocholines and carbohydrates in women. In addition, we found that women had shorter length of hospitalization than men and metabolic characteristics may contribute to predict the duration from positive to negative in non-severe COVID-19 patients. Collectively, this study shed light on sex-specific metabolic shifts in non-severe COVID-19 patients during the recovery process, suggesting a sex bias in prognostic and therapeutic evaluations based on metabolic profiling.
format Online
Article
Text
id pubmed-8021501
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Research Network of Computational and Structural Biotechnology
record_format MEDLINE/PubMed
spelling pubmed-80215012021-04-06 Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process Zheng, Hong Jin, Shengwei Li, Ting Ying, Weiyang Ying, Binyu Chen, Dong Ning, Jie Zheng, Chanfan Li, Yuping Li, Chen Chen, Chengshui Li, Xiaokun Gao, Hongchang Comput Struct Biotechnol J Research Article Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC–MS-based untargeted metabolomics to analyze plasma metabolic characteristics in men and women with non-severe COVID-19 at both acute period and 30 days after discharge. The results demonstrate that metabolic alterations in plasma of COVID-19 patients during the recovery and rehabilitation process were presented in a sex specific manner. Overall, the levels of most metabolites were increased in COVID-19 patients after the cure relative to acute period. The major plasma metabolic changes were identified including fatty acids in men and glycerophosphocholines and carbohydrates in women. In addition, we found that women had shorter length of hospitalization than men and metabolic characteristics may contribute to predict the duration from positive to negative in non-severe COVID-19 patients. Collectively, this study shed light on sex-specific metabolic shifts in non-severe COVID-19 patients during the recovery process, suggesting a sex bias in prognostic and therapeutic evaluations based on metabolic profiling. Research Network of Computational and Structural Biotechnology 2021-04-06 /pmc/articles/PMC8021501/ /pubmed/33841749 http://dx.doi.org/10.1016/j.csbj.2021.03.039 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Zheng, Hong
Jin, Shengwei
Li, Ting
Ying, Weiyang
Ying, Binyu
Chen, Dong
Ning, Jie
Zheng, Chanfan
Li, Yuping
Li, Chen
Chen, Chengshui
Li, Xiaokun
Gao, Hongchang
Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process
title Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process
title_full Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process
title_fullStr Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process
title_full_unstemmed Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process
title_short Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process
title_sort metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe covid-19 patients during recovery process
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021501/
https://www.ncbi.nlm.nih.gov/pubmed/33841749
http://dx.doi.org/10.1016/j.csbj.2021.03.039
work_keys_str_mv AT zhenghong metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT jinshengwei metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT liting metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT yingweiyang metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT yingbinyu metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT chendong metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT ningjie metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT zhengchanfan metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT liyuping metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT lichen metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT chenchengshui metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT lixiaokun metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess
AT gaohongchang metabolomicsrevealssexspecificmetabolicshiftsandpredictsthedurationfrompositivetonegativeinnonseverecovid19patientsduringrecoveryprocess