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Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress
CHK1 is a crucial DNA damage checkpoint kinase and its activation, which requires ATR and RAD17, leads to inhibition of DNA replication and cell cycle progression. Recently, we reported that SMG7 stabilizes and activates p53 to induce G(1) arrest upon DNA damage; here we show that SMG7 plays a criti...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021557/ https://www.ncbi.nlm.nih.gov/pubmed/33820915 http://dx.doi.org/10.1038/s41598-021-86957-x |