Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis

Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the vent...

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Autores principales: Coronel, Ruben, Potse, Mark, Haïssaguerre, Michel, Derval, Nicolas, Rivaud, Mathilde R., Meijborg, Veronique M. F., Cluitmans, Matthijs, Hocini, Mélèze, Boukens, Bastiaan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021688/
https://www.ncbi.nlm.nih.gov/pubmed/33833689
http://dx.doi.org/10.3389/fphys.2021.648396
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author Coronel, Ruben
Potse, Mark
Haïssaguerre, Michel
Derval, Nicolas
Rivaud, Mathilde R.
Meijborg, Veronique M. F.
Cluitmans, Matthijs
Hocini, Mélèze
Boukens, Bastiaan J.
author_facet Coronel, Ruben
Potse, Mark
Haïssaguerre, Michel
Derval, Nicolas
Rivaud, Mathilde R.
Meijborg, Veronique M. F.
Cluitmans, Matthijs
Hocini, Mélèze
Boukens, Bastiaan J.
author_sort Coronel, Ruben
collection PubMed
description Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.
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spelling pubmed-80216882021-04-07 Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis Coronel, Ruben Potse, Mark Haïssaguerre, Michel Derval, Nicolas Rivaud, Mathilde R. Meijborg, Veronique M. F. Cluitmans, Matthijs Hocini, Mélèze Boukens, Bastiaan J. Front Physiol Physiology Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF. Frontiers Media S.A. 2021-03-23 /pmc/articles/PMC8021688/ /pubmed/33833689 http://dx.doi.org/10.3389/fphys.2021.648396 Text en Copyright © 2021 Coronel, Potse, Haïssaguerre, Derval, Rivaud, Meijborg, Cluitmans, Hocini and Boukens. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Coronel, Ruben
Potse, Mark
Haïssaguerre, Michel
Derval, Nicolas
Rivaud, Mathilde R.
Meijborg, Veronique M. F.
Cluitmans, Matthijs
Hocini, Mélèze
Boukens, Bastiaan J.
Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis
title Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis
title_full Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis
title_fullStr Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis
title_full_unstemmed Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis
title_short Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis
title_sort why ablation of sites with purkinje activation is antiarrhythmic: the interplay between fast activation and arrhythmogenesis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021688/
https://www.ncbi.nlm.nih.gov/pubmed/33833689
http://dx.doi.org/10.3389/fphys.2021.648396
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