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Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients

The COVID-19 pandemic continues to prevail as a catastrophic wave infecting over 111 million people globally, claiming 2. 4 million lives to date. Aged individuals are particularly vulnerable to this disease due to their fraility, immune dysfunction, and higher rates of medical comorbidities, among...

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Detalles Bibliográficos
Autores principales: Mainali, Shraddha, Darsie, Marin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021699/
https://www.ncbi.nlm.nih.gov/pubmed/33833676
http://dx.doi.org/10.3389/fnagi.2021.648662
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author Mainali, Shraddha
Darsie, Marin E.
author_facet Mainali, Shraddha
Darsie, Marin E.
author_sort Mainali, Shraddha
collection PubMed
description The COVID-19 pandemic continues to prevail as a catastrophic wave infecting over 111 million people globally, claiming 2. 4 million lives to date. Aged individuals are particularly vulnerable to this disease due to their fraility, immune dysfunction, and higher rates of medical comorbidities, among other causes. Apart from the primary respiratory illness, this virus is known to cause multi-organ dysfunction including renal, cardiac, and neurologic injuries, particularly in the critically-ill cohorts. Elderly patients 65 years of age or older are known to have more severe systemic disease and higher rates of neurologic complications. Morbidity and mortality is very high in the elderly population with 6–930 times higher likelihood of death compared to younger cohorts, with the highest risk in elderly patients ≥85 years and especially those with medical comorbidities such as hypertension, diabetes, heart disease, and underlying respiratory illness. Commonly reported neurologic dysfunctions of COVID-19 include headache, fatigue, dizziness, and confusion. Elderly patients may manifest atypical presentations like fall or postural instability. Other important neurologic dysfunctions in the elderly include cerebrovascular diseases, cognitive impairment, and neuropsychiatric illnesses. Elderly patients with preexisting neurologic diseases are susceptibility to severe COVID-19 infection and higher rates of mortality. Treatment of neurologic dysfunction of COVID-19 is based on existing practice standards of specific neurologic condition in conjunction with systemic treatment of the viral illness. The physical, emotional, psychologic, and financial implications of COVID-19 pandemic have been severe. Long-term data are still needed to understand the lasting effects of this devastating pandemic.
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spelling pubmed-80216992021-04-07 Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients Mainali, Shraddha Darsie, Marin E. Front Aging Neurosci Neuroscience The COVID-19 pandemic continues to prevail as a catastrophic wave infecting over 111 million people globally, claiming 2. 4 million lives to date. Aged individuals are particularly vulnerable to this disease due to their fraility, immune dysfunction, and higher rates of medical comorbidities, among other causes. Apart from the primary respiratory illness, this virus is known to cause multi-organ dysfunction including renal, cardiac, and neurologic injuries, particularly in the critically-ill cohorts. Elderly patients 65 years of age or older are known to have more severe systemic disease and higher rates of neurologic complications. Morbidity and mortality is very high in the elderly population with 6–930 times higher likelihood of death compared to younger cohorts, with the highest risk in elderly patients ≥85 years and especially those with medical comorbidities such as hypertension, diabetes, heart disease, and underlying respiratory illness. Commonly reported neurologic dysfunctions of COVID-19 include headache, fatigue, dizziness, and confusion. Elderly patients may manifest atypical presentations like fall or postural instability. Other important neurologic dysfunctions in the elderly include cerebrovascular diseases, cognitive impairment, and neuropsychiatric illnesses. Elderly patients with preexisting neurologic diseases are susceptibility to severe COVID-19 infection and higher rates of mortality. Treatment of neurologic dysfunction of COVID-19 is based on existing practice standards of specific neurologic condition in conjunction with systemic treatment of the viral illness. The physical, emotional, psychologic, and financial implications of COVID-19 pandemic have been severe. Long-term data are still needed to understand the lasting effects of this devastating pandemic. Frontiers Media S.A. 2021-03-23 /pmc/articles/PMC8021699/ /pubmed/33833676 http://dx.doi.org/10.3389/fnagi.2021.648662 Text en Copyright © 2021 Mainali and Darsie. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Mainali, Shraddha
Darsie, Marin E.
Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients
title Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients
title_full Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients
title_fullStr Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients
title_full_unstemmed Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients
title_short Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients
title_sort neurologic and neuroscientific evidence in aged covid-19 patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021699/
https://www.ncbi.nlm.nih.gov/pubmed/33833676
http://dx.doi.org/10.3389/fnagi.2021.648662
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