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CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment

The crosstalk between tumor cells and the tumor microenvironment (TME), triggers a variety of critical signaling pathways and promotes the malignant progression of cancer. The success rate of cancer therapy through targeting single molecule of this crosstalk may be extremely low, whereas co-targetin...

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Autores principales: Jia, Qingan, Xu, Binghui, Zhang, Yaoyao, Ali, Arshad, Liao, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021874/
https://www.ncbi.nlm.nih.gov/pubmed/33833779
http://dx.doi.org/10.3389/fgene.2021.649387
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author Jia, Qingan
Xu, Binghui
Zhang, Yaoyao
Ali, Arshad
Liao, Xia
author_facet Jia, Qingan
Xu, Binghui
Zhang, Yaoyao
Ali, Arshad
Liao, Xia
author_sort Jia, Qingan
collection PubMed
description The crosstalk between tumor cells and the tumor microenvironment (TME), triggers a variety of critical signaling pathways and promotes the malignant progression of cancer. The success rate of cancer therapy through targeting single molecule of this crosstalk may be extremely low, whereas co-targeting multiple components could be complicated design and likely to have more side effects. The six members of cellular communication network (CCN) family proteins are scaffolding proteins that may govern the TME, and several studies have shown targeted therapy of CCN family proteins may be effective for the treatment of cancer. CCN protein family shares similar structures, and they mutually reinforce and neutralize each other to serve various roles that are tightly regulated in a spatiotemporal manner by the TME. Here, we review the current knowledge on the structures and roles of CCN proteins in different types of cancer. We also analyze CCN mRNA expression, and reasons for its diverse relationship to prognosis in different cancers. In this review, we conclude that the discrepant functions of CCN proteins in different types of cancer are attributed to diverse TME and CCN truncated isoforms, and speculate that targeting CCN proteins to rebalance the TME could be a potent anti-cancer strategy.
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spelling pubmed-80218742021-04-07 CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment Jia, Qingan Xu, Binghui Zhang, Yaoyao Ali, Arshad Liao, Xia Front Genet Genetics The crosstalk between tumor cells and the tumor microenvironment (TME), triggers a variety of critical signaling pathways and promotes the malignant progression of cancer. The success rate of cancer therapy through targeting single molecule of this crosstalk may be extremely low, whereas co-targeting multiple components could be complicated design and likely to have more side effects. The six members of cellular communication network (CCN) family proteins are scaffolding proteins that may govern the TME, and several studies have shown targeted therapy of CCN family proteins may be effective for the treatment of cancer. CCN protein family shares similar structures, and they mutually reinforce and neutralize each other to serve various roles that are tightly regulated in a spatiotemporal manner by the TME. Here, we review the current knowledge on the structures and roles of CCN proteins in different types of cancer. We also analyze CCN mRNA expression, and reasons for its diverse relationship to prognosis in different cancers. In this review, we conclude that the discrepant functions of CCN proteins in different types of cancer are attributed to diverse TME and CCN truncated isoforms, and speculate that targeting CCN proteins to rebalance the TME could be a potent anti-cancer strategy. Frontiers Media S.A. 2021-03-23 /pmc/articles/PMC8021874/ /pubmed/33833779 http://dx.doi.org/10.3389/fgene.2021.649387 Text en Copyright © 2021 Jia, Xu, Zhang, Ali and Liao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Jia, Qingan
Xu, Binghui
Zhang, Yaoyao
Ali, Arshad
Liao, Xia
CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment
title CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment
title_full CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment
title_fullStr CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment
title_full_unstemmed CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment
title_short CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment
title_sort ccn family proteins in cancer: insight into their structures and coordination role in tumor microenvironment
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021874/
https://www.ncbi.nlm.nih.gov/pubmed/33833779
http://dx.doi.org/10.3389/fgene.2021.649387
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