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Fully human antibody V(H) domains to generate mono and bispecific CAR to target solid tumors

BACKGROUND: Chimeric antigen receptor (CAR) T cells are effective in B-cell malignancies. However, heterogeneous antigen expression and antigen loss remain important limitations of targeted immunotherapy in solid tumors. Therefore, targeting multiple tumor-associated antigens simultaneously is expec...

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Detalles Bibliográficos
Autores principales:	Wang, Guanmeng, Zhou, Xin, Fucà, Giovanni, Dukhovlinova, Elena, Shou, Peishun, Li, Hongxia, Johnston, Colette, Mcguinness, Brian, Dotti, Gianpietro, Du, Hongwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021891/ https://www.ncbi.nlm.nih.gov/pubmed/33795386 http://dx.doi.org/10.1136/jitc-2020-002173

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