Cargando…

Effect of dialysis and transplantation on myocardial repolarization parameters and P‐wave dispersion in chronic kidney disease

BACKGROUND: Chronic kidney disease (CKD) patients are at higher risk for cardiac arrhythmias. The risk of arrhythmia may change with different treatment modalities. We proposed to compare the effects of varied therapy methods on myocardial repolarization parameters (Tp‐e, QT, QTc intervals, Tp‐e/QT,...

Descripción completa

Detalles Bibliográficos
Autores principales: Akcay, Murat, Yıldırım, Ufuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022004/
https://www.ncbi.nlm.nih.gov/pubmed/33850576
http://dx.doi.org/10.1002/joa3.12511
_version_ 1783674853924012032
author Akcay, Murat
Yıldırım, Ufuk
author_facet Akcay, Murat
Yıldırım, Ufuk
author_sort Akcay, Murat
collection PubMed
description BACKGROUND: Chronic kidney disease (CKD) patients are at higher risk for cardiac arrhythmias. The risk of arrhythmia may change with different treatment modalities. We proposed to compare the effects of varied therapy methods on myocardial repolarization parameters (Tp‐e, QT, QTc intervals, Tp‐e/QT, Tp‐e/QTc ratios) and P‐wave dispersion (PWD) in patients with CKD. METHODS: Three groups were formed from the patients aged between 18 and 65 years, as Group 1 consisting of CKD patients receiving hemodialysis (HD) three times a week, Group 2 consisting of predialysis CKD patients and Group 3 consisting of CKD patients who underwent successful transplantation. All patients’ basic demographic data, risk factors, and echocardiographic parameters were recorded, and electrocardiographic repolarization parameters and PWD were analyzed. RESULTS: The PR, QT, and QTc intervals were significantly shorter in the transplantation group compared to the other groups (P = .020, P < .001, P = .035; respectively). Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios were significantly higher in the predialysis group compared to the other groups (P < .001, P < .001, P = .001; respectively), while there was no significant variation between the HD and transplantation groups (P > .05). PWD was significantly increased in the predialysis group compared to other two groups (P < .001), while no significant variation between the HD and transplantation groups was observed. CONCLUSION: We found that the Tp‐e interval, Tp‐e/QT, Tp‐e/QTc, and PWD were significantly higher in the predialysis CKD group, but the PR, QT, and QTc intervals were significantly shorter in the transplantation group compared to the other groups. The prognostic significance and prediction of these parameters in arrhythmic events in CKD patients requires further evaluation with long‐time follow‐up.
format Online
Article
Text
id pubmed-8022004
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-80220042021-04-12 Effect of dialysis and transplantation on myocardial repolarization parameters and P‐wave dispersion in chronic kidney disease Akcay, Murat Yıldırım, Ufuk J Arrhythm Original Articles BACKGROUND: Chronic kidney disease (CKD) patients are at higher risk for cardiac arrhythmias. The risk of arrhythmia may change with different treatment modalities. We proposed to compare the effects of varied therapy methods on myocardial repolarization parameters (Tp‐e, QT, QTc intervals, Tp‐e/QT, Tp‐e/QTc ratios) and P‐wave dispersion (PWD) in patients with CKD. METHODS: Three groups were formed from the patients aged between 18 and 65 years, as Group 1 consisting of CKD patients receiving hemodialysis (HD) three times a week, Group 2 consisting of predialysis CKD patients and Group 3 consisting of CKD patients who underwent successful transplantation. All patients’ basic demographic data, risk factors, and echocardiographic parameters were recorded, and electrocardiographic repolarization parameters and PWD were analyzed. RESULTS: The PR, QT, and QTc intervals were significantly shorter in the transplantation group compared to the other groups (P = .020, P < .001, P = .035; respectively). Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios were significantly higher in the predialysis group compared to the other groups (P < .001, P < .001, P = .001; respectively), while there was no significant variation between the HD and transplantation groups (P > .05). PWD was significantly increased in the predialysis group compared to other two groups (P < .001), while no significant variation between the HD and transplantation groups was observed. CONCLUSION: We found that the Tp‐e interval, Tp‐e/QT, Tp‐e/QTc, and PWD were significantly higher in the predialysis CKD group, but the PR, QT, and QTc intervals were significantly shorter in the transplantation group compared to the other groups. The prognostic significance and prediction of these parameters in arrhythmic events in CKD patients requires further evaluation with long‐time follow‐up. John Wiley and Sons Inc. 2021-02-08 /pmc/articles/PMC8022004/ /pubmed/33850576 http://dx.doi.org/10.1002/joa3.12511 Text en © 2021 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Akcay, Murat
Yıldırım, Ufuk
Effect of dialysis and transplantation on myocardial repolarization parameters and P‐wave dispersion in chronic kidney disease
title Effect of dialysis and transplantation on myocardial repolarization parameters and P‐wave dispersion in chronic kidney disease
title_full Effect of dialysis and transplantation on myocardial repolarization parameters and P‐wave dispersion in chronic kidney disease
title_fullStr Effect of dialysis and transplantation on myocardial repolarization parameters and P‐wave dispersion in chronic kidney disease
title_full_unstemmed Effect of dialysis and transplantation on myocardial repolarization parameters and P‐wave dispersion in chronic kidney disease
title_short Effect of dialysis and transplantation on myocardial repolarization parameters and P‐wave dispersion in chronic kidney disease
title_sort effect of dialysis and transplantation on myocardial repolarization parameters and p‐wave dispersion in chronic kidney disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022004/
https://www.ncbi.nlm.nih.gov/pubmed/33850576
http://dx.doi.org/10.1002/joa3.12511
work_keys_str_mv AT akcaymurat effectofdialysisandtransplantationonmyocardialrepolarizationparametersandpwavedispersioninchronickidneydisease
AT yıldırımufuk effectofdialysisandtransplantationonmyocardialrepolarizationparametersandpwavedispersioninchronickidneydisease