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Prevention of Dementia in Patients with Atrial Fibrillation
Atrial fibrillation (AF) is the most common form of arrhythmia in the elderly population and increases stroke risk by a factor of 4- to 5-fold. There is increasing evidence to suggest that incident AF may contribute to the development of dementia, independent of overt stroke. In particular, relative...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Cardiology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022029/ https://www.ncbi.nlm.nih.gov/pubmed/33821580 http://dx.doi.org/10.4070/kcj.2021.0027 |
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author | Kim, Daehoon Yang, Pil-Sung Joung, Boyoung |
author_facet | Kim, Daehoon Yang, Pil-Sung Joung, Boyoung |
author_sort | Kim, Daehoon |
collection | PubMed |
description | Atrial fibrillation (AF) is the most common form of arrhythmia in the elderly population and increases stroke risk by a factor of 4- to 5-fold. There is increasing evidence to suggest that incident AF may contribute to the development of dementia, independent of overt stroke. In particular, relatively younger patients with AF are more prone to dementia development than older patients with AF. Evidence is accumulating regarding the possible treatment strategies for preventing dementia in patients with AF. Oral anticoagulation may be effective for reducing the risk of dementia, even in patients with low stroke risks. Among oral anticoagulants, the use of non-vitamin K antagonists have been associated with a considerably decreased risk of dementia than warfarin. Moreover, successful catheter ablation for AF has also been associated with decreased dementia risk compared to medical therapy, suggesting that restoration of sinus rhythm, and not the ablation procedure itself, as the important mechanism in the prevention of AF-associated dementia. Among midlife patients with AF, there appeared to be a U-shaped association of blood pressure (BP) and a linear association of hypertension with dementia risk. A BP of 120 to 129/80 to 84 mmHg has been identified as the optimal range. Finally, integrated management of AF was associated with a reduced risk of dementia in AF patients. |
format | Online Article Text |
id | pubmed-8022029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Korean Society of Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-80220292021-04-13 Prevention of Dementia in Patients with Atrial Fibrillation Kim, Daehoon Yang, Pil-Sung Joung, Boyoung Korean Circ J State of the Art Review Atrial fibrillation (AF) is the most common form of arrhythmia in the elderly population and increases stroke risk by a factor of 4- to 5-fold. There is increasing evidence to suggest that incident AF may contribute to the development of dementia, independent of overt stroke. In particular, relatively younger patients with AF are more prone to dementia development than older patients with AF. Evidence is accumulating regarding the possible treatment strategies for preventing dementia in patients with AF. Oral anticoagulation may be effective for reducing the risk of dementia, even in patients with low stroke risks. Among oral anticoagulants, the use of non-vitamin K antagonists have been associated with a considerably decreased risk of dementia than warfarin. Moreover, successful catheter ablation for AF has also been associated with decreased dementia risk compared to medical therapy, suggesting that restoration of sinus rhythm, and not the ablation procedure itself, as the important mechanism in the prevention of AF-associated dementia. Among midlife patients with AF, there appeared to be a U-shaped association of blood pressure (BP) and a linear association of hypertension with dementia risk. A BP of 120 to 129/80 to 84 mmHg has been identified as the optimal range. Finally, integrated management of AF was associated with a reduced risk of dementia in AF patients. The Korean Society of Cardiology 2021-03-11 /pmc/articles/PMC8022029/ /pubmed/33821580 http://dx.doi.org/10.4070/kcj.2021.0027 Text en Copyright © 2021. The Korean Society of Cardiology https://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | State of the Art Review Kim, Daehoon Yang, Pil-Sung Joung, Boyoung Prevention of Dementia in Patients with Atrial Fibrillation |
title | Prevention of Dementia in Patients with Atrial Fibrillation |
title_full | Prevention of Dementia in Patients with Atrial Fibrillation |
title_fullStr | Prevention of Dementia in Patients with Atrial Fibrillation |
title_full_unstemmed | Prevention of Dementia in Patients with Atrial Fibrillation |
title_short | Prevention of Dementia in Patients with Atrial Fibrillation |
title_sort | prevention of dementia in patients with atrial fibrillation |
topic | State of the Art Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022029/ https://www.ncbi.nlm.nih.gov/pubmed/33821580 http://dx.doi.org/10.4070/kcj.2021.0027 |
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