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Red cell alloantibodies in beta-thalassaemia major patients’ blood referring to the regional blood transfusion center of Tehran, Iran

[Image: see text] Introduction: Thalassemia is associated with a genetic decline in the rate of synthesis of one or more types of natural hemoglobin polypeptide chains. One of the major complications in thalassemia patients is alloimmunization, which is antibody production by the patient against tra...

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Autores principales: Ebrahimisadr, Parisa, Bakhshandeh, Zahra, Majidiani, Hamidreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences (TUOMS Publishing Group) 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022230/
https://www.ncbi.nlm.nih.gov/pubmed/33842283
http://dx.doi.org/10.34172/bi.2021.20
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author Ebrahimisadr, Parisa
Bakhshandeh, Zahra
Majidiani, Hamidreza
author_facet Ebrahimisadr, Parisa
Bakhshandeh, Zahra
Majidiani, Hamidreza
author_sort Ebrahimisadr, Parisa
collection PubMed
description [Image: see text] Introduction: Thalassemia is associated with a genetic decline in the rate of synthesis of one or more types of natural hemoglobin polypeptide chains. One of the major complications in thalassemia patients is alloimmunization, which is antibody production by the patient against transfused red blood cells (RBCs). These RBCs are unknown by the recipient and the formed antibodies against them are called alloantibodies. This study aimed to evaluate the frequency of alloantibodies against RBCs in beta-thalassemia patients referred to Tehran Regional Blood Transfusion Center. Methods: In this study, antibody screening tests (Dia-cell I, II, and III) were performed on 184 thalassemia patients. An identification test by the Dia panel consisting of 11 different O RBCs groups to examine sera with Dia cells (I, II, or III) was performed. Results: In our study, males and females patients comprised 66 (35.87%) and 118 (64.13%), respectively, of whom 116 (63%) had alloimmunization. In addition, 68 thalassemia subjects (37%) lacked alloantibodies. Among 184 patients with beta-thalassemia major, anti-K (Kell system), anti-D, and anti-E (Rhesus system) had the most abundant alloantibody variants with an incidence of 24 (13%), 11 (5.98%), and 10 (5.4%), respectively. Conclusion: Before RBC transfusion, regular RBC antigen phenotypes, as well as problem-solving of alloantibody production by receiving compatible blood for Kell and RH subgroups, are suggested for all cases of transfusion-derived thalassemia.
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spelling pubmed-80222302021-04-09 Red cell alloantibodies in beta-thalassaemia major patients’ blood referring to the regional blood transfusion center of Tehran, Iran Ebrahimisadr, Parisa Bakhshandeh, Zahra Majidiani, Hamidreza Bioimpacts Original Research [Image: see text] Introduction: Thalassemia is associated with a genetic decline in the rate of synthesis of one or more types of natural hemoglobin polypeptide chains. One of the major complications in thalassemia patients is alloimmunization, which is antibody production by the patient against transfused red blood cells (RBCs). These RBCs are unknown by the recipient and the formed antibodies against them are called alloantibodies. This study aimed to evaluate the frequency of alloantibodies against RBCs in beta-thalassemia patients referred to Tehran Regional Blood Transfusion Center. Methods: In this study, antibody screening tests (Dia-cell I, II, and III) were performed on 184 thalassemia patients. An identification test by the Dia panel consisting of 11 different O RBCs groups to examine sera with Dia cells (I, II, or III) was performed. Results: In our study, males and females patients comprised 66 (35.87%) and 118 (64.13%), respectively, of whom 116 (63%) had alloimmunization. In addition, 68 thalassemia subjects (37%) lacked alloantibodies. Among 184 patients with beta-thalassemia major, anti-K (Kell system), anti-D, and anti-E (Rhesus system) had the most abundant alloantibody variants with an incidence of 24 (13%), 11 (5.98%), and 10 (5.4%), respectively. Conclusion: Before RBC transfusion, regular RBC antigen phenotypes, as well as problem-solving of alloantibody production by receiving compatible blood for Kell and RH subgroups, are suggested for all cases of transfusion-derived thalassemia. Tabriz University of Medical Sciences (TUOMS Publishing Group) 2021 2020-04-20 /pmc/articles/PMC8022230/ /pubmed/33842283 http://dx.doi.org/10.34172/bi.2021.20 Text en © 2021 The Author(s) This work is published by BioImpacts as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Research
Ebrahimisadr, Parisa
Bakhshandeh, Zahra
Majidiani, Hamidreza
Red cell alloantibodies in beta-thalassaemia major patients’ blood referring to the regional blood transfusion center of Tehran, Iran
title Red cell alloantibodies in beta-thalassaemia major patients’ blood referring to the regional blood transfusion center of Tehran, Iran
title_full Red cell alloantibodies in beta-thalassaemia major patients’ blood referring to the regional blood transfusion center of Tehran, Iran
title_fullStr Red cell alloantibodies in beta-thalassaemia major patients’ blood referring to the regional blood transfusion center of Tehran, Iran
title_full_unstemmed Red cell alloantibodies in beta-thalassaemia major patients’ blood referring to the regional blood transfusion center of Tehran, Iran
title_short Red cell alloantibodies in beta-thalassaemia major patients’ blood referring to the regional blood transfusion center of Tehran, Iran
title_sort red cell alloantibodies in beta-thalassaemia major patients’ blood referring to the regional blood transfusion center of tehran, iran
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022230/
https://www.ncbi.nlm.nih.gov/pubmed/33842283
http://dx.doi.org/10.34172/bi.2021.20
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