Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides

[Image: see text] Thiocyanates, versatile building blocks in organic synthesis, are shown to be easily accessible via an interrupted Pummerer reaction of sulfoxides. This facile dealkylative functionalization proceeds under mild conditions through electrophilic activation of the sulfoxide partner. T...

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Autores principales: Todorović, Uroš, Klose, Immo, Maulide, Nuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022320/
https://www.ncbi.nlm.nih.gov/pubmed/33724046
http://dx.doi.org/10.1021/acs.orglett.1c00460
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author Todorović, Uroš
Klose, Immo
Maulide, Nuno
author_facet Todorović, Uroš
Klose, Immo
Maulide, Nuno
author_sort Todorović, Uroš
collection PubMed
description [Image: see text] Thiocyanates, versatile building blocks in organic synthesis, are shown to be easily accessible via an interrupted Pummerer reaction of sulfoxides. This facile dealkylative functionalization proceeds under mild conditions through electrophilic activation of the sulfoxide partner. The resulting thiocyanate itself can serve as a handle for diversification in a straightforward one-pot procedure.
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spelling pubmed-80223202021-04-06 Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides Todorović, Uroš Klose, Immo Maulide, Nuno Org Lett [Image: see text] Thiocyanates, versatile building blocks in organic synthesis, are shown to be easily accessible via an interrupted Pummerer reaction of sulfoxides. This facile dealkylative functionalization proceeds under mild conditions through electrophilic activation of the sulfoxide partner. The resulting thiocyanate itself can serve as a handle for diversification in a straightforward one-pot procedure. American Chemical Society 2021-03-16 2021-04-02 /pmc/articles/PMC8022320/ /pubmed/33724046 http://dx.doi.org/10.1021/acs.orglett.1c00460 Text en © 2021 The Authors. Published by American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Todorović, Uroš
Klose, Immo
Maulide, Nuno
Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides
title Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides
title_full Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides
title_fullStr Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides
title_full_unstemmed Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides
title_short Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides
title_sort straightforward access to thiocyanates via dealkylative cyanation of sulfoxides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022320/
https://www.ncbi.nlm.nih.gov/pubmed/33724046
http://dx.doi.org/10.1021/acs.orglett.1c00460
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AT maulidenuno straightforwardaccesstothiocyanatesviadealkylativecyanationofsulfoxides

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