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Fantastic databases and where to find them: Web applications for researchers in a rush

Public databases are essential to the development of multi-omics resources. The amount of data created by biological technologies needs a systematic and organized form of storage, that can quickly be accessed, and managed. This is the objective of a biological database. Here, we present an overview...

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Detalles Bibliográficos
Autores principales: Villalba, Gerda Cristal, Matte, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022358/
https://www.ncbi.nlm.nih.gov/pubmed/33821874
http://dx.doi.org/10.1590/1678-4685-GMB-2020-0203
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author Villalba, Gerda Cristal
Matte, Ursula
author_facet Villalba, Gerda Cristal
Matte, Ursula
author_sort Villalba, Gerda Cristal
collection PubMed
description Public databases are essential to the development of multi-omics resources. The amount of data created by biological technologies needs a systematic and organized form of storage, that can quickly be accessed, and managed. This is the objective of a biological database. Here, we present an overview of human databases with web applications. The databases and tools allow the search of biological sequences, genes and genomes, gene expression patterns, epigenetic variation, protein-protein interactions, variant frequency, regulatory elements, and comparative analysis between human and model organisms. Our goal is to provide an opportunity for exploring large datasets and analyzing the data for users with little or no programming skills. Public user-friendly web-based databases facilitate data mining and the search for information applicable to healthcare professionals. Besides, biological databases are essential to improve biomedical search sensitivity and efficiency and merge multiple datasets needed to share data and build global initiatives for the diagnosis, prognosis, and discovery of new treatments for genetic diseases. To show the databases at work, we present a a case study using ACE2 as example of a gene to be investigated. The analysis and the complete list of databases is available in the following website <https://kur1sutaru.github.io/fantastic_databases_and_where_to_find_them/>.
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spelling pubmed-80223582021-04-15 Fantastic databases and where to find them: Web applications for researchers in a rush Villalba, Gerda Cristal Matte, Ursula Genet Mol Biol Genomics and Bioinformatics Public databases are essential to the development of multi-omics resources. The amount of data created by biological technologies needs a systematic and organized form of storage, that can quickly be accessed, and managed. This is the objective of a biological database. Here, we present an overview of human databases with web applications. The databases and tools allow the search of biological sequences, genes and genomes, gene expression patterns, epigenetic variation, protein-protein interactions, variant frequency, regulatory elements, and comparative analysis between human and model organisms. Our goal is to provide an opportunity for exploring large datasets and analyzing the data for users with little or no programming skills. Public user-friendly web-based databases facilitate data mining and the search for information applicable to healthcare professionals. Besides, biological databases are essential to improve biomedical search sensitivity and efficiency and merge multiple datasets needed to share data and build global initiatives for the diagnosis, prognosis, and discovery of new treatments for genetic diseases. To show the databases at work, we present a a case study using ACE2 as example of a gene to be investigated. The analysis and the complete list of databases is available in the following website <https://kur1sutaru.github.io/fantastic_databases_and_where_to_find_them/>. Sociedade Brasileira de Genética 2021-04-02 /pmc/articles/PMC8022358/ /pubmed/33821874 http://dx.doi.org/10.1590/1678-4685-GMB-2020-0203 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Genomics and Bioinformatics
Villalba, Gerda Cristal
Matte, Ursula
Fantastic databases and where to find them: Web applications for researchers in a rush
title Fantastic databases and where to find them: Web applications for researchers in a rush
title_full Fantastic databases and where to find them: Web applications for researchers in a rush
title_fullStr Fantastic databases and where to find them: Web applications for researchers in a rush
title_full_unstemmed Fantastic databases and where to find them: Web applications for researchers in a rush
title_short Fantastic databases and where to find them: Web applications for researchers in a rush
title_sort fantastic databases and where to find them: web applications for researchers in a rush
topic Genomics and Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022358/
https://www.ncbi.nlm.nih.gov/pubmed/33821874
http://dx.doi.org/10.1590/1678-4685-GMB-2020-0203
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